Blocking AHR May Unleash Nerve Regrowth After Injury
Mount Sinai researchers identify the aryl hydrocarbon receptor (AHR) as a molecular brake that shifts injured neurons toward managing stress rather than regrowing connections. Inhibiting AHR in mouse models enhances axon regeneration and improves movement and sensation, by allowing a growth-focused protein production program and involving the HIF-1α pathway. The study suggests AHR inhibitors or gene therapy could potentially boost nerve repair after injuries to the peripheral nerves or spinal cord, but further work is needed before clinical use.