Tag

Allergic Diseases

All articles tagged with #allergic diseases

health1 month ago•55 min saved

Birth Order Across the Human Phenome: Broad Patterns in Disease Risk

Two designs in over 5 million two‑child families from Merative MarketScan scanned 569 diseases. The primary between‑family matched cohort (1.6 million pairs) and a within‑family sibling comparison (5.1 million families) identified 150 Bonferroni‑significant birth‑order associations among 418 diseases. First‑borns have higher risk for neurodevelopmental and immune/allergic conditions (e.g., other/unspecified PDD, autism, food allergy, allergic rhinitis) while second‑borns show higher odds for substance‑abuse disorders and certain digestive diseases (gastritis/duodenitis). Across designs, effects are broadly concordant (r ≈ 0.66; 74% concordant; 84.7% of Bonferroni hits agree in direction), robust to state fixed effects and full‑sibling restrictions. A phenome‑wide atlas reveals domain‑specific patterns: first‑born excess dominates neuropsychiatric conditions; second‑born excess appears in digestive, musculoskeletal, infectious and some neurological diseases. The study provides a comprehensive, robust map of birth‑order influences on human disease and shows spacing between siblings can modulate several associations.

via Nature|

#allergic-diseases #birth-order #epidemiology

health1 year ago•1 min saved

Amish Lifestyle May Hold Key to Avoiding Allergies

The Amish are remarkably resistant to allergies, with only 7% of Amish children testing positive for common allergens, making them one of the least allergic populations in the developed world, unlike the general U.S. population and other traditional farming communities.

via The Boston Globe|

#allergic-diseases #allergies #amish

health1 year ago•0 min saved

Amish Lifestyle May Hold Key to Allergy Resistance

The Amish are nearly immune to allergies, with only 7% of Amish children showing allergic responses compared to over 50% of the general U.S. population, making them a mystery to experts studying allergies.

via The Washington Post|

#allergic-diseases #allergies #amish

health3 years ago•4 min saved

Unveiling the Shared Source of Childhood Allergies

A study led by researchers at the University of British Columbia and BC Children's Hospital has found that several major childhood allergies, including eczema, asthma, food allergy, and hay fever, may have a common origin in the gut microbiome. The study examined the gut microbiota of 1,115 children from birth to age five and identified a bacterial signature associated with the development of these allergies. Factors such as antibiotic usage in the first year of life were found to increase the risk of allergies, while breastfeeding for the first six months was protective. The findings could lead to methods of predicting and preventing childhood allergies.

via Medical Xpress|

#allergic-diseases #childhood-allergies #gut-microbiome