All articles tagged with #cardiac repair
New mouse research shows coronary collateral arteries mainly arise from capillary endothelial cells converting into arteries, not from enlarging preexisting arteries. A VEGF-driven pathway promotes capillary-to-artery transformation, suggesting potential therapies to stimulate de novo collateral formation and improve cardiac repair after arterial blockages.
Researchers in mice and pigs showed a single intramuscular injection of self-amplifying RNA (saRNA) increased the heart-healing hormone ANP, helping heart muscle recover after a heart attack. The saRNA acts like mRNA but sustains protein production for weeks, and the delivery mirrors COVID-19 vaccines. While promising, the approach has not been tested in humans, and future trials are needed to establish safety, dosing, and efficacy before clinical use.