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Claudin 4

All articles tagged with #claudin 4

science12 days ago•7 min saved

Claudin-4 Receptor Unmasks How Gut Bacteria Trigger Colorectal Cancer

Researchers at Johns Hopkins have shown that the Bacteroides fragilis toxin (BFT) must bind the host receptor claudin-4 to damage colon cells. Using a genome-wide CRISPR screen, the team identified claudin-4 as the critical link, confirmed the direct BFT-claudin-4 interaction biophysically, and demonstrated that a soluble claudin-4 decoy protected mice from toxin-induced colon injury, suggesting a possible preventive approach against toxin-driven colorectal cancer.

via SciTechDaily|

#bacteroides-fragilis #claudin-4 #colorectal-cancer

science1 month ago•74 min saved

Bacterial toxin hijacks claudin-4 to cleave E-cadherin, fueling colorectal cancer risk

Researchers identify claudin-4 as the receptor for enterotoxigenic Bacteroides fragilis toxin (BFT) and show that BFT binding to claudin-4 enables direct cleavage of the E-cadherin ectodomain at the cell surface, disrupting the epithelial barrier and triggering pro-carcinogenic signaling. A genome-wide CRISPR screen highlighted claudin-4 as a key determinant of BFT toxicity, with validation in multiple cell lines and a mouse model. Importantly, a soluble claudin-4 analogue blocks BFT activity both in vitro and in vivo, suggesting a potential therapeutic approach to prevent ETBF-associated colorectal neoplasia and infection.

via Nature|

#bft #claudin-4 #colorectal-cancer