Tag

Bacteroides Fragilis

All articles tagged with #bacteroides fragilis

science13 days ago•7 min saved

Claudin-4 Receptor Unmasks How Gut Bacteria Trigger Colorectal Cancer

Researchers at Johns Hopkins have shown that the Bacteroides fragilis toxin (BFT) must bind the host receptor claudin-4 to damage colon cells. Using a genome-wide CRISPR screen, the team identified claudin-4 as the critical link, confirmed the direct BFT-claudin-4 interaction biophysically, and demonstrated that a soluble claudin-4 decoy protected mice from toxin-induced colon injury, suggesting a possible preventive approach against toxin-driven colorectal cancer.

via SciTechDaily|

#bacteroides-fragilis #claudin-4 #colorectal-cancer

science1 month ago•5 min saved

Researchers uncover hidden gut virus tied to colorectal cancer

A Danish-led study identifies a previously unknown bacteriophage inside the gut bacterium Bacteroides fragilis that is more common in individuals with colorectal cancer, a pattern replicated in independent cohorts from Europe, the US, and Asia. While the virus–bacterium interaction may help explain cancer risk and could become a future stool-based screening marker, causality is not yet established, and researchers are pursuing further experiments in gut models, tumor tissue, and animal studies.

via SciTechDaily|

#bacteriophage #bacteroides-fragilis #colorectal-cancer

science2 months ago•4 min saved

Virus Inside Gut Bacteria Linked to Colorectal Cancer, Study Finds

A Danish study identified a previously unknown bacteriophage inside the gut bacterium Bacteroides fragilis that is more commonly found in people with colorectal cancer. In a larger cohort, patients with cancer were about twice as likely to carry detectable levels of the phage, suggesting a virus–bacterium interaction may influence cancer risk and could inform future screening or treatment approaches. Causality has not been established, and more research is needed.

via ScienceAlert|

#bacteriophage #bacteroides-fragilis #colorectal-cancer

health2 years ago•3 min saved

"Discovery of Unconventional Pathway for Antibiotic Resistance"

Researchers at the Marine Biological Laboratory have discovered a novel genetic arrangement in the common gut bacterium Bacteroides fragilis that may help it protect itself from tetracycline, a widely used antibiotic. This finding sheds light on previously unseen genetic arrangements that confer antibiotic resistance and may aid in developing new ways to limit the spread of antibiotic resistance genes. The study, published in the journal mBio, reveals the presence of mobile genetic elements called transposons, which play a key role in horizontal gene transfer and the development of antibiotic resistance in bacteria.

via Phys.org|

#antibiotic-resistance #bacteroides-fragilis #genetic-arrangement