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Cross Presentation

All articles tagged with #cross presentation

Peripheral dendritic cell priming drives CD8+ T cell–mediated tau neurodegeneration
science1 month ago

Peripheral dendritic cell priming drives CD8+ T cell–mediated tau neurodegeneration

A tauopathy mouse study shows conventional dendritic cell 1 (cDC1)–dependent cross-presentation of brain-derived antigens in peripheral lymphoid tissues primes CD8+ T cells that infiltrate the brain and worsen tau-related neurodegeneration; removing cDC1s or disrupting cross-presentation protects against neuronal loss and reduces brain T cell accumulation, highlighting a peripheral brain–immune axis as a potential therapeutic target.

via Nature|
#cd8-t-cells#cdc1#cross-presentation
mRNA vaccines prime CD8+ T cells through two dendritic routes and cross-dressed MHC-I
science5 months ago

mRNA vaccines prime CD8+ T cells through two dendritic routes and cross-dressed MHC-I

Nature reports that mRNA–LNP vaccines prime CD8+ T cells not through the classic cDC1 cross-presentation, but via redundant input from both cDC1 and cDC2 dendritic cells; a substantial portion of priming comes from cross-dressing—peptide–MHC-I complexes transferred from non-hematopoietic cells in a type I interferon–dependent process—broadening T-cell activation to antigens not encoded by the vaccine and supporting anti-tumor immunity and memory.

via Nature|
#cd8-t-cells#cross-dressing#cross-presentation