estrogen-only therapy linked to lower dementia signals in menopause women
A retrospective analysis across two datasets (21,462 records, including nearly 3,000 brain donors) found that estrogen-only hormone therapy for menopause was associated with fewer memory problems and lower Alzheimer’s biomarkers in brains. The study shows association, not causation, and could be influenced by confounding factors or missing data (e.g., hysterectomy status); more long-term randomized trials are needed to determine any protective effect.