
Brain-targeted menopause drug Veoza offers non-hormonal relief for hot flashes
Veoza (fezolinetant) is a non-hormonal treatment for menopausal vasomotor symptoms that works by blocking the NK3 receptor in the hypothalamus, dampening the brain’s temperature-regulation signals rather than replacing hormones. In trials, three months of treatment reduced daily hot flashes/night sweats from about 10–12 to around 4–5, but it does not address other estrogen-deficiency symptoms like mood changes, vaginal dryness, or bone health. Side effects can include headaches, nausea, abdominal pain and insomnia, and liver function monitoring is recommended; Veoza is an alternative for those who can’t take HRT, with newer options like Lynkuet potentially offering improvements in safety and efficacy.




