Tag

Estrogen

All articles tagged with #estrogen

Midlife Brain Fog: Distinguishing ADHD from Perimenopause
health4 days ago

Midlife Brain Fog: Distinguishing ADHD from Perimenopause

The article explains that midlife brain fog can be caused by hormonal changes during perimenopause or by ADHD, with estrogen and dopamine playing key roles in mood, sleep, memory and focus. ADHD typically begins in childhood, while perimenopause-related cognitive changes appear later, but the two can overlap or even be present together. For those unsure, tracking symptoms over weeks (including pattern across cycles, sleep, work and home life) and discussing detailed examples with a clinician can help determine whether ADHD, perimenopause, or both, warrants specific support.

Brain estrogen in both sexes shapes memory's resilience to stress
neuroscience21 days ago

Brain estrogen in both sexes shapes memory's resilience to stress

Researchers in mice show that estrogen produced in the hippocampus alters memory after acute stress in a sex- and cycle-dependent way: high hippocampal estrogen in males and proestrus females worsened memory, while estrus females with lower estrogen were more resilient. The findings suggest estrogen receptors regulate chromatin and memory-related genes, with potential implications for PTSD risk and aging in humans—especially during perimenopause—though further study is needed.

Menopause Reframes the Brain: Resting Networks Reorganize Across Midlife
science1 month ago

Menopause Reframes the Brain: Resting Networks Reorganize Across Midlife

A two-year study tracking resting-state brain activity across premenopause, perimenopause, and postmenopause found widespread, estrogen-linked changes in functional networks, indicating menopause is a neurological transition that may explain short-term cognitive symptoms and influence long-term brain aging. The work, published in Menopause, emphasizes that resting-state measurements reveal brain reorganization not captured by task-based tests and notes ongoing trials comparing natural hormonal trajectories with hormone therapy to protect brain health as women age; with about 6,000 US women entering menopause daily, the findings have broad public-health implications.

Estrogen Loss May Erode the Brain's ECM, Elevating Women's Alzheimer's Risk
science1 month ago

Estrogen Loss May Erode the Brain's ECM, Elevating Women's Alzheimer's Risk

A preclinical Northwestern study shows that postmenopausal estrogen loss, aging, and female sex drive degradation of the hippocampal extracellular matrix (ECM), weakening the brain's supportive scaffold and potentially increasing Alzheimer's risk in women; findings suggest therapies focused on ECM repair or brain estrogen signaling rather than solely clearing amyloid plaques.

Trauma Hit During High Estrogen Predicts PTSD Risk
science2 months ago

Trauma Hit During High Estrogen Predicts PTSD Risk

A new study links the brain’s estrogen levels at the moment of trauma to PTSD risk: high hippocampal estrogen boosts neural plasticity, enabling more intense, lasting traumatic memories in both sexes, with memory disruption persisting longer in females due to receptor differences; the work suggests future treatments could target estrogen signaling to reduce long-term trauma effects.

Medications That May Trigger Gynecomastia in Men
health3 months ago

Medications That May Trigger Gynecomastia in Men

An article lists 10 medicines linked to gynecomastia in men, explaining how hormone balance shifts—lower testosterone, higher estrogen, or raised prolactin—can enlarge breast tissue. Drugs highlighted include spironolactone, finasteride, anabolic steroids, antipsychotics, nonsteroidal antiandrogens, diazepam, cimetidine, ketoconazole, and metronidazole. In many cases the condition resolves after stopping the drug, but it can linger and may require treatment or surgery in some men.

Doctors Urge Expanded Awareness of Hormone Replacement Therapy for Women
health-and-fitness3 months ago

Doctors Urge Expanded Awareness of Hormone Replacement Therapy for Women

Doctors say estrogen replacement can benefit many women by addressing hormonal fluctuations that affect the menstrual cycle, heart, bones, and brain; despite past fears from the Women’s Health Initiative and FDA warnings, updated research and guidance are expanding who should consider HRT, with estrogen levels that can require multiple tests to monitor; it's never too late to start for postmenopausal or younger patients experiencing imbalance.

Estrogen may amplify gut pain, offering clues to IBS gender gap
health5 months ago

Estrogen may amplify gut pain, offering clues to IBS gender gap

A new preclinical mouse study suggests estrogen heightens gut-pain sensitivity by acting on rare gut-lining L-cells, which increases OLFR78 receptor activity and boosts serotonin release via the PYY pathway, altering nerve signaling to the brain. Removing ovaries lowers estrogen and reduces pain sensitivity, while restoring estrogen brings it back, potentially explaining why IBS is more common and severe in women. The findings hint at potential targets (PYY/OLFR78) for IBS therapies, though translating mouse results to humans requires caution.

Democrats laud FDA move to lift estrogen therapy warning
health-care5 months ago

Democrats laud FDA move to lift estrogen therapy warning

The House Democratic Women’s Caucus praised the FDA and HHS Secretary Kennedy Jr. for removing the black-box warning on estrogen-based hormone replacement therapy, saying the change reflects science-based regulation. They urged continued research into safety and effectiveness, increased menopause research funding, better labeling and postmarket oversight, in a letter to Kennedy and FDA Commissioner Makary, with signatures from a broad group of Democratic lawmakers.

FDA to Remove Black Box Warnings on Menopause Hormone Therapy
health8 months ago

FDA to Remove Black Box Warnings on Menopause Hormone Therapy

Science and medical guidelines have evolved, leading to a more nuanced view of hormone therapy for menopause. Starting therapy before age 60 or within ten years of menopause can provide relief from symptoms like hot flashes and night sweats, and offer benefits for bone and heart health. However, not all women are suitable candidates, and risks vary depending on the type of estrogen used and individual health conditions. Alternatives like non-hormonal medications and lifestyle changes are also available for managing menopausal symptoms.