L-Arginine Stabilizes Protein Droplets to Halt Alzheimer’s Fibril Formation
UB scientists report that the cellular metabolite L-arginine stabilizes Tau-containing protein droplets, delaying their surface-initiated transition into toxic fibrils linked to Alzheimer’s while preserving the droplets’ ability to assemble microtubules; this demonstrates that droplet formation and fibril formation are separable and points to therapies that block fibril formation without disrupting condensate function (Nature Communications, 2026).