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Hepatocyte Growth Factor

All articles tagged with #hepatocyte growth factor

science2 hours ago•5 min saved

LASSS Antioxidant Shows Promise in Rejuvenating Aging Muscle Repair

Age-related nitration impairs hepatocyte growth factor (HGF), a key muscle-repair signal. In a Scientific Reports study, two sulfur-based antioxidants (GSSSG and LASSS) reduced HGF nitration, but LASSS not only protected HGF but also enhanced its interaction with the c-met receptor, effectively boosting muscle-repair signaling in mouse models. While promising, these results need validation in humans and longer-term studies to assess potential in preventing age-related muscle loss (sarcopenia) and frailty.

via ScienceAlert|

#aging #antioxidants #hepatocyte-growth-factor

health8 days ago•110 min saved

LASSS compound shows promise for preserving muscle during aging in mice

Scientists report a mouse study finding two compounds can protect hepatocyte growth factor (HGF) from nitration during muscle disuse, helping satellite cells activate and potentially slowing age-related muscle loss. In experiments, the compound LASSS (lipoic acid trisulfide) reduced HGF nitration and boosted receptor binding; when given in drinking water to disused mice, LASSS lowered nitration around muscle cells, suggesting a mechanism to preserve muscle. While promising, the researchers caution that aging effects require longer studies and safety in older animals, and it remains to be seen whether these findings translate to humans.

via Live Science|

#health #hepatocyte-growth-factor #lipoic-acid-trisulfide