Microscopic milliseconds: footage shows cancer cell slipping past immune surveillance
Using high-speed 3D live-cell imaging, researchers captured the exact moment a cancer cell escapes an immune T cell, revealing a rapid sequence of signals, cytoskeletal changes, and micro-bleb formation that loosen adhesion. The study introduces a time-resolved view of immune checkpoints and suggests new targets and timing for therapies like checkpoint inhibitors and CAR-T strategies, though it remains limited to controlled systems and needs validation in tissue contexts.