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Hiv Reservoir

All articles tagged with #hiv reservoir

science1 month ago•9 min saved

Diabetes drug metformin hints at long-term HIV control after stopping therapy

New immunology research links specific immune-cell patterns and two genes (DDIT4 and ZNF254) to longer ART-free control of HIV; metformin can activate one of these mechanisms to keep HIV dormant, delaying or potentially preventing rebound after treatment interruption. Analyses of ART-interruption trials showed higher levels of stem cell–memory CD8+ T cells and certain natural killer cells associated with slower rebound. This supports a block-and-lock strategy using metformin or similar drugs, with preclinical and clinical testing planned by the HOPE Collaboratory to pursue HIV silencing while reducing inflammation.

via SciTechDaily|

#hiv #hiv-reservoir #immune-cells

health11 months ago•4 min saved

Major Breakthroughs in HIV Cure Research Overwhelm Scientists

Researchers have developed a new mRNA delivery method using specialized lipid nanoparticles to make hidden HIV in white blood cells visible, potentially paving the way for a cure, though further research and trials are needed.

via The Guardian|

#health #hiv-cure #hiv-reservoir

health2 years ago•10 min saved

"Revolutionary HIV Drugs: Turning the Tables on Infection by Clearing Infected Cells"

Scientists from Merck have discovered a subset of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs that not only inhibit HIV's ability to replicate but also cause the virus to kill off infected cells. These drugs, called Targeted Activators of Cell Kill (TACK), work by prematurely synthesizing HIV's protease enzyme, which then snips out cellular proteins that form a self-destruct bomb, destroying the infected cell. The TACK drugs offer a potential cure therapy that specifically targets HIV-infected cells, without relying on host immune responses. The lead candidate, Pyr01, has shown promising results in lab experiments, demonstrating strong antiviral activity and the ability to kill HIV-infected cells. Further research is needed to determine the safety and effectiveness of TACK drugs in clinical settings.

via aidsmap|

#health #hiv #hiv-reservoir