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Immune Cells

All articles tagged with #immune cells

New Map of Aging Breast Tissue Reveals Why Cancer Risk Increases with Age
science26 days ago

New Map of Aging Breast Tissue Reveals Why Cancer Risk Increases with Age

A study analyzing normal breast tissue from 527 women (over 3 million cells) created a detailed map of how breast tissue changes with age, finding dramatic remodeling around menopause—shrinking milk-producing lobules, fewer epithelial and immune cells, increased fat, and a shift to a tissue environment that can better support cancer development. Younger breasts had more cancer-fighting B- and T-cells, while older breast tissue showed fewer of these cells and more pro-cancer immune cells like M2 macrophages, helping explain why breast cancer risk rises with age. The work, published in Nature Aging, underscores how aging tissue and immune landscape contribute to cancer susceptibility.

via ScienceAlert|
#aging#breast-cancer#breast-tissue
Diabetes drug metformin hints at long-term HIV control after stopping therapy
science1 month ago

Diabetes drug metformin hints at long-term HIV control after stopping therapy

New immunology research links specific immune-cell patterns and two genes (DDIT4 and ZNF254) to longer ART-free control of HIV; metformin can activate one of these mechanisms to keep HIV dormant, delaying or potentially preventing rebound after treatment interruption. Analyses of ART-interruption trials showed higher levels of stem cell–memory CD8+ T cells and certain natural killer cells associated with slower rebound. This supports a block-and-lock strategy using metformin or similar drugs, with preclinical and clinical testing planned by the HOPE Collaboratory to pursue HIV silencing while reducing inflammation.

via SciTechDaily|
#hiv#hiv-reservoir#immune-cells
Zombie COVID Fragments Attack Immune Cells, Fuel Long COVID
science3 months ago

Zombie COVID Fragments Attack Immune Cells, Fuel Long COVID

New research shows leftover fragments from SARS-CoV-2 form protein pieces that bind to curved membranes on immune cells, suppressing dendritic cells and T cells and potentially driving long-COVID; Omicron fragments appear less damaging to these cells, highlighting variant differences while underscoring ongoing COVID risks and the value of vaccination.

via ScienceAlert|
#dendritic-cells#immune-cells#long-covid
Skin Immune Cells Trigger Hidden Psoriatic Arthritis
health3 months ago

Skin Immune Cells Trigger Hidden Psoriatic Arthritis

Researchers found that immune cells formed in inflamed psoriasis skin can migrate into the bloodstream and travel to joints, where they encounter fibroblasts and ignite inflammation leading to psoriatic arthritis. The study explains why only some psoriasis patients develop arthritis and suggests blood-d detectable migratory cells could serve as an early warning, with future therapies aiming to intercept these cells before joint damage occurs.

via SciTechDaily|
#fibroblasts#health#immune-cells
Genetics and environment jointly sculpt the immune cell epigenome
science3 months ago

Genetics and environment jointly sculpt the immune cell epigenome

Single-cell methylome and chromatin-accessibility analysis across 171 PBMC samples shows that genetic variation and environmental exposures independently shape immune cell epigenomes, with exposure- and genotype-associated regions showing distinct genomic enrichments (eDMRs at enhancers, gDMRs in gene bodies); colocalization of meQTLs with disease GWAS signals provides cell-type-specific insights into how genetics and environment influence health and disease.

via Nature|
#edmr#epigenetics#gdmr
Breastfeeding boosts immune cells, potentially reducing breast cancer risk
health7 months ago

Breastfeeding boosts immune cells, potentially reducing breast cancer risk

Research shows that breastfeeding leaves long-lasting immune cells in the breast, particularly CD8+ T-cells, which help protect against breast cancer, especially aggressive types like triple-negative breast cancer. These immune cells remain for decades and are associated with better outcomes, suggesting potential for new preventive strategies and therapies.

via The Guardian|
#breast-cancer#breastfeeding#health