Tag

Mace

All articles tagged with #mace

business25 days ago•2 min saved

Novo's ziltivekimab flops in CKD trial; Artemis and Hermes face uphill path

Novo Nordisk's Zeus phase 3 trial of ziltivekimab failed to reduce major adverse cardiovascular events in patients with CKD and inflammation, despite IL-6 pathway inhibition; the hazard ratio was 0.99, missing the clinically meaningful 0.85 target and causing the trial to miss its primary endpoint. Artemis and Hermes remain the next tests, though analysts have grown skeptical, given the potential multibillion-dollar CKD opportunity and a peak sales projection around $3 billion previously attached to the program. Readouts for Artemis/Hermes are expected in the first half of next year, leaving the pipeline contingent on those results.

via Fierce Biotech|

#business #ckd #il-6

business25 days ago•3 min saved

Novo Nordisk slides after heart-drug trial misses key endpoint

Novo Nordisk’s shares tumbled after late-stage results showed ziltivekimab, an IL-6 pathway blocker, did not reduce major adverse cardiovascular events (MACE) versus placebo in patients with ASCVD, CKD and elevated inflammation; while the drug showed a biological effect, it failed to show a statistically meaningful MACE benefit and serious infections were more common, with no difference in overall mortality. The company says the result doesn’t change its cardiovascular strategy as it faces U.S. market pressure and Eli Lilly’s competing therapies, and investors will watch next week’s Q2 earnings for pipeline updates.

via CNBC|

#business #glp-1 #mace

health2 months ago•5 min saved

Updated COVID Vaccines Continue to Shield Heart Health, Large VA Study Finds

A large VA-based study in JAMA Internal Medicine finds the 2024–2025 updated COVID-19 vaccine continues to protect against COVID-19–associated major adverse cardiovascular events (MACE), with about 38% effectiveness and a reduction from roughly 5 to 3 events per 10,000 people over about 8 months, especially among those 75+ and with underlying conditions; an accompanying report shows vaccines also cut hospitalization and severe illness by about 35% and 41%; however, generalizability is limited due to the veteran, older, mostly male population, and antivaccine rhetoric remains a challenge. The findings support continued booster use.

via Ars Technica|

#cardiovascular-risk #covid-19 #health

politics4 months ago•177 min saved

Mace–Mills spat tests GOP unity in the House

Rep. Nancy Mace and Rep. Cory Mills have escalated a long-running feud on Capitol Hill, with Mace threatening a floor vote to expel Mills over ethics allegations while Mills denies wrongdoing and calls it political theater. Speaker Mike Johnson said he doesn’t back intra-party expulsions as the House Ethics Committee reviews the cases, a dynamic that could strain the Republicans’ razor-thin majority. Some GOP members, including Rep. Lauren Boebert, have hinted they might vote to expel if warranted, underscoring the risk to party unity as leadership tries to navigate the controversy.

via CNN|

#expulsion #gop #house-of-representatives

crime3 years ago•0 min saved

"Rising Concerns: Increased Security Measures Implemented at High School Football Games Across the Nation"

A juvenile has been arrested for causing a disturbance at a high school football game in Shreveport by spraying mace at a group of students, prompting the game to be postponed. The student has been charged with intimidation and interference in the operation of a public school.

via KSLA|

#arrest #crime #disturbance

crime3 years ago•0 min saved

Incidents, Entertainment, Cancellations, and Heat: Highlights from Olmsted County Fair

Law enforcement responded to two incidents at the Olmsted County Fair in Minnesota. The first incident involved two groups of young teens fighting, which started at the fair. When officers arrived, the groups scattered and the teens were uncooperative. Shortly after, a woman from a group of young adults sprayed mace towards several people, causing exposure to fairgoers. The Rochester Fire Department treated minor cases of exposure, and some individuals of interest are being interviewed.

via KTTC|

#crime #fighting #law-enforcement