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Mafld

All articles tagged with #mafld

health1 month ago•7 min saved

Silent signals: catching liver cancer before it whispers

Liver cancer often grows quietly due to the liver’s large reserve capacity, so early signs are vague and easily mistaken for other issues. Key warning signs include unexplained weight loss, persistent fatigue, reduced appetite, and right‑sided abdominal pain; as it progresses, ascites and jaundice may appear. Those with hepatitis B or C, cirrhosis, MAFLD, or a family history are at higher risk. Early detection via blood tests (including liver function and AFP), ultrasound, CT or MRI improves treatment outcomes, with regular surveillance recommended for high‑risk groups. Preventive steps include hepatitis vaccination, limiting alcohol, maintaining a healthy weight, managing diabetes and fatty liver disease, and routine health screenings.

via The Times of India|

#early-symptoms #health #hepatitis-b

health3 months ago•4 min saved

Resmetirom May Guard Against Fatty Liver-Linked Liver Cancer, Study Finds

A HKU-led preclinical study using a fatty liver disease mouse model and single-cell RNA sequencing suggests Resmetirom, FDA-approved for MAFLD, could prevent or slow fatty liver–related liver cancer by lowering the cancer-promoting MDK pathway and reshaping immune cells. Resmetirom reduced liver fat and tumor growth and lowered MDK levels, with stronger effects when combined with MDK inhibitors. Researchers plan biomarker validation and clinical trials combining Resmetirom with immunotherapy or targeted therapies to pursue a prevention-first approach for high-risk patients.

via SciTechDaily|

#health #hepatocellular-carcinoma #immunotherapy

medical-research-news3 years ago•2 min saved

Rising prevalence of metabolic-associated fatty liver disease in the US

The prevalence of metabolic-associated fatty liver disease (MAFLD), the leading global cause of liver disease, is increasing in the US, with Mexican Americans consistently having the highest percentage. MAFLD is a risk factor for cardiovascular disease, type 2 diabetes, and a common type of liver cancer. The increase in MAFLD is concerning, as this condition can lead to liver failure and cardiovascular diseases and has an important health disparity. The percent of people with MAFLD increased from 16% in 1988 to 37% in 2018, while the percent of obesity rose from 23% in 1988 to 40% in 2018.

via News-Medical.Net|

#cardiovascular-disease #diabetes #liver-disease

health3 years ago•6 min saved

The Alarming Rise of Metabolic-Associated Fatty Liver Disease in the US

The prevalence of metabolic associated fatty liver disease (MAFLD) is increasing significantly in the United States, with a 131% increase from 1988 to 2018. MAFLD is the leading global cause of liver disease and is linked to genetics, obesity, diabetes, and abnormal levels of fats in the blood. Mexican Americans have a higher prevalence of MAFLD, but the increase in prevalence was more profound among non-Hispanic whites. A healthy diet and exercise can help reduce the risk of developing the disease, which can be reversed if detected early.

via Medical News Today|

#diabetes #health #healthy-lifestyle