Tag

Diabetes

All articles tagged with #diabetes

health-and-medicine11 days ago•15 min saved

Cholesterol drug cuts first cardiovascular events by 31% in diabetics without artery disease

A Mass General Brigham study finds the PCSK9 inhibitor evolocumab, added to standard therapy, reduces the risk of a first major cardiovascular event by 31% over ~5 years in high‑risk diabetics without diagnosed atherosclerosis, with about a 51% drop in LDL‑C. Safety was similar to placebo, suggesting earlier intensive cholesterol lowering may prevent heart attacks and strokes in patients without established artery disease; results were presented at the ACC and published in JAMA.

via ScienceDaily|

#cardiovascular-disease #diabetes #evolocumab

health11 days ago•17 min saved

Brief High-Intensity Bursts May Boost Health More Than Longer Workouts

A UK Biobank analysis found that spending at least 4% of weekly time in vigorous, breathless activity lowered risks of eight chronic diseases (including dementia and type 2 diabetes) and reduced overall mortality over seven years; intensity mattered more than total activity, and even roughly 15–20 minutes per week of such effort added to daily life (stairs, brisk walking, active play) was linked to meaningful health benefits.

via Gizmodo|

#dementia #diabetes #health

business13 days ago•4 min saved

Lilly bets $2B on AI-driven diabetes drug with Insilico

U.S. drugmaker Eli Lilly is poised to sign a roughly $2 billion deal with Hong Kong-listed Insilico Medicine to use AI in drug discovery, securing exclusive rights to sell Insilico’s GLP-1 diabetes drug with an upfront $115 million and potential milestone payments that could lift the total beyond $2 billion, underscoring Lilly’s China-focused expansion and its heavy AI investment in pharma.

via Financial Times|

#artificial-intelligence #business #diabetes

science13 days ago•23 min saved

Mini Pancreas Devices, AI Echo Chambers, and Epstein Files: A 2026 News Roundup

A four-story roundup covers MIT's implantable device that encapsulates insulin-producing pancreatic islet cells with an onboard oxygen generator to potentially treat Type 1 diabetes, a study showing AI chatbots bias users toward being right and undermining accountability, a Maryland homeowner allegedly calling ICE on immigrant roofers, and newly released Epstein files detailing guard conduct and related financial records that fuel ongoing speculation and scrutiny.

via jezebel.com|

#artificial-intelligence #biotech #crime

technology14 days ago•4 min saved

Oxygen-powered implant lets encapsulated islet cells regulate diabetes without immunosuppression

MIT researchers have developed an implantable, encapsulated islet-cell device with an onboard oxygen generator that protects the cells from immune attack and sustains insulin production. In mice and rats, the device functioned for at least 90 days, maintaining healthy blood glucose by the donor or stem-cell–derived islets, with wireless power delivery boosting oxygen supply. The team aims to extend durability to years and explore delivering other protein therapies in the body.

via MIT News|

#diabetes #immune-protection #implantable-device

health15 days ago•2 min saved

Agave and Stevia Highlighted as Lower-GI Alternatives for Stable Blood Sugar

Dietitians and an endocrinologist say swapping table sugar for lower‑GI sweeteners can help avoid blood sugar spikes in diabetes. Agave nectar has a relatively low glycemic index (~20) due to its high fructose content, while stevia offers a zero‑calorie option; both should be used in moderation as individual responses vary. The key message is to limit added sugars and choose preferred, lower‑GI substitutes when possible.

via Prevention|

#agave #blood-sugar #diabetes

health15 days ago•260 min saved

Agave Nectar Emerges as Top Natural Sweetener for Stable Blood Sugar

Dietitians and a doctor say agave nectar is the number-one natural sweetener less likely to spike blood sugar, due to a low glycemic index (about 20) and a fructose-rich profile compared with table sugar. They suggest using agave as a moderate substitute in drinks or baking, while noting stevia as another no-sugar option. Overall, reducing added sugars remains important for diabetics or prediabetics, and the best choice depends on personal taste and moderation.

via AOL.com|

#agave #blood-sugar #diabetes

health15 days ago•6 min saved

New Oral GLP-1 Pill Shifts the Weight-Loss Race Against Ozempic

A 52-week phase-3 trial in 1,698 adults with type 2 diabetes across six countries found orforglipron, a daily oral small-molecule GLP-1 drug, reduced HbA1c more and produced greater weight loss than oral semaglutide (1.71–1.91% vs 1.47% HbA1c and 6.1–8.2 kg vs 5.3 kg), but caused more gastrointestinal side effects and higher discontinuation (~10% vs 4–5%). It’s cheaper to manufacture and doesn’t require refrigeration, giving it logistical advantages, though long-term comparisons with injectable GLP-1 therapies and obesity trials without diabetes are still underway.

via ScienceAlert|

#diabetes #glp-1 #health

health18 days ago•2 min saved

Stopping GLP-1 Drugs Sparks Quick Loss of Heart-Protection Benefits

A BMJ Medicine analysis of about 333,000 adults with diabetes found that consistent GLP-1 use lowers cardiovascular risk by 18% over three years, but stopping for as little as six months can raise risk by up to 8%, and pausing for one to two years can increase risk by roughly 22%, erasing the drug’s protection. Weight regain and a rebound in inflammation, blood pressure, and cholesterol accompany interruptions, which can leave a lasting “metabolic whiplash.” With many patients stopping or pausing due to cost, side effects, or shortages, the findings underscore the importance of maintaining GLP-1 therapy where possible.

via Futurism|

#cardiovascular-risk #diabetes #glp-1

health20 days ago•4 min saved

Old Diabetes Drug Metformin Shows Brain-Led Control of Metabolism

New preclinical work links metformin’s metabolic effects to the brain, showing it acts in the hypothalamus via the Rap1 pathway to enhance central insulin signaling and reduce liver glucose production in mice. This brain-first mechanism could reshape diabetes and obesity therapies, informing drug combinations and trial endpoints, but human validation is needed and questions remain about dosing, blood–brain barrier crossing, and interactions with AMPK.

via Iowa Park Leader|

#brain-metabolism #diabetes #health

health23 days ago•3 min saved

GLP-1 Weight-Loss Drugs Linked to Lower Depression and Anxiety Risks in Large Study

A Lancet Psychiatry study of more than 95,000 patients using GLP-1 diabetes/weight‑loss medications (notably semaglutide) found substantially lower risks of worsening mental illness, depression, anxiety, substance-use disorders, self-harm, and related hospital care. While the results suggest a potential mental-health benefit, the study is observational and cannot establish causality; clinical trials are needed to determine if the drugs themselves improve mental health beyond weight loss.

via Euronews.com|

#diabetes #glp-1 #health

health23 days ago•6 min saved

Seven hours of sleep linked to lower diabetes risk, study finds

A large observational study of about 25,000 people (2009–2023) found that roughly seven hours and 18 minutes of nightly sleep was associated with the lowest insulin resistance, while both shorter and longer sleep linked to worse metabolic markers; weekend catch-up sleep did not offset deficits, and self-reported data limit causal conclusions. Experts say sleep is important for metabolic health but not a standalone solution, with guidance generally suggesting about 7–9 hours of regular, high‑quality sleep to help reduce diabetes risk.

via Fox News|

#bmj-open-diabetes-research-and-care #diabetes #health

science23 days ago•7 min saved

Gut-Penetrating Peptide Brings Insulin Closer to an Oral Pill

Researchers at Kumamoto University developed a cyclic DNP peptide that enables insulin to cross the intestinal barrier, achieving about 33–41% oral bioavailability in diabetic mouse models. They demonstrated two approaches—a mixing method where the peptide interacts with zinc-stabilized insulin hexamers, and a covalent DNP–insulin conjugate created via click chemistry—both producing effective glucose lowering. Once-daily dosing maintained normal glycemia for three days, marking a significant step toward practical oral insulin and potentially reducing injectable insulin needs; translational studies in larger animals and human intestinal systems are planned.

via SciTechDaily|

#diabetes #drug-delivery #insulin-bioavailability

health23 days ago•3 min saved

Discontinuing GLP-1 Diabetes Drugs Elevates Cardiovascular Risk

A Washington University study of more than 333,000 adults with type 2 diabetes found that even short gaps in GLP-1 therapy (such as six months) erase much of the cardiovascular protection these drugs provide, with longer interruptions raising the risk of heart attack, stroke and death; discontinuation due to side effects and access barriers remains high, underscoring the need for sustained treatment and better strategies to keep patients on GLP-1 medications like Ozempic/Wegovy.

via CNBC|

#cardiovascular-risk #diabetes #glp-1

health23 days ago•185 min saved

Heart benefits from GLP-1 meds fade after stopping, large study finds

A large BMJ Medicine study using Veterans Health Administration records found that cardiovascular benefits from GLP-1 injections fade quickly after stopping the drugs: risk of heart attack, stroke and related events rises by about 4% at six months, 14% at one year, and 22% by the second year off therapy, approaching pre-treatment levels. The findings suggest ongoing GLP-1 treatment is needed to maintain heart benefits, with the advantage appearing to be partly weight-independent, as seen in related obesity trials.

via CNN|

#bmj-medicine #diabetes #glp-1