Tag

Diabetes

All articles tagged with #diabetes

science16 hours ago•5 min saved

Metformin May Boost Lifespan for Older Women, Study Suggests

A long-term, observational study of 438 postmenopausal women with type 2 diabetes found that those who started metformin had about a 30% lower risk of dying before age 90 compared with those starting a sulfonylurea. The researchers caution that the design cannot prove causation, with no placebo group and limited generalizability to men or younger people, but the roughly 14–15 years of follow-up adds evidence to metformin’s potential anti-aging effects and the geroscience hypothesis, warranting randomized trials.

via ScienceAlert|

#aging #diabetes #longevity

science21 hours ago•8 min saved

Trojan-Horse Weight-Loss Molecule Delivers Potent Results in Mice

Scientists at Helmholtz Munich created a hybrid 'Trojan horse' drug that uses GLP-1R/GIPR signaling as an entry door and carries lanifibranor to activate PPARα/γ/δ inside cells, hitting five targets. In diet-induced obese mice, it reduced appetite, produced greater weight loss, and improved blood glucose versus reference therapies, with GI side effects similar to current incretin medicines. The approach is preclinical; whether results translate to humans remains to be seen and will require clinical development.

via SciTechDaily|

#diabetes #gip #glp-1

health2 days ago•9 min saved

GLP-1 Weight-Loss Drugs: Common Side Effects and Management Tips

GLP-1 medications like Ozempic, Wegovy, and Zepbound can aid weight loss but commonly cause side effects ranging from GI symptoms (nausea, vomiting, constipation/diarrhea) to dehydration, pancreatitis, gallstones, gastroparesis, and dental issues. Doctors advise staying hydrated, prioritizing protein, maintaining strength training, and timing meals (avoid eating 3–4 hours before bed), while reporting persistent or severe symptoms. Long-term risks are still unknown, so these drugs should be used under medical guidance for those who meet criteria.

via HuffPost|

#diabetes #gastrointestinal #glp-1

science5 days ago•7 min saved

Metformin’s Hidden Target: The Gut Takes Center Stage

New Northwestern University research in mice shows metformin mainly acts in the intestine, lowering blood sugar by reducing mitochondrial activity in gut cells and prompting them to burn more glucose, challenging the idea that the liver is the primary target. Published in Nature Metabolism, the study links berberine to a similar gut pathway and uses engineered mice to show that blocking mitochondrial complex I in the gut is central to metformin’s effect, with implications for gut-targeted diabetes therapies.

via SciTechDaily|

#diabetes #gut #intestine

science5 days ago•6 min saved

Full-plant cannabis extract improves glucose tolerance in mice, unlike THC alone

In a mouse study, obese mice on a high-fat, high-sugar diet treated with THC lost weight and body fat, but only those given a full-plant cannabis extract showed improved glucose tolerance; THC alone did not yield this metabolic benefit, suggesting other cannabis compounds drive the positive effects. The work, published in The Journal of Physiology, cautions against drawing human conclusions and highlights the need for further research into non-THC cannabinoids like CBG and other plant compounds.

via ScienceAlert|

#cannabis #diabetes #metabolism

science8 days ago•35 min saved

Non-THC Cannabis Compounds Drive Metabolic Benefits, Study Finds

A mouse study shows that while pure THC can promote weight loss, it does not improve glucose control; a whole-plant cannabis extract containing THC and other cannabinoids did improve glucose tolerance and metabolic markers, indicating non-THC compounds drive metabolic benefits and could inform safer, non‑psychoactive diabetes therapies. Researchers caution against using cannabis for weight loss until more is known and plan to identify the active compounds.

via Earth.com|

#cannabis #diabetes #metabolism

health10 days ago•7 min saved

Ultra-Processed Foods Linked to Higher Heart Disease Risk, New ESC Consensus Warns

A European Heart Journal consensus from the European Society of Cardiology links high ultra-processed food (UPF) intake with greater risks of heart disease, atrial fibrillation, and cardiovascular death, as well as obesity and diabetes; the authors urge clinicians to ask about UPF consumption, advocate for clearer labeling and stronger regulations, and note that most evidence is observational while long-term trials are needed.

via SciTechDaily|

#cardiovascular-risk #diabetes #health

health10 days ago•5 min saved

From insulin to iron: a 53-year-old's 100-pound weight loss and bodybuilding journey

Jim Anders, 53, of Corpus Christi, Texas, went from nearly 300 pounds and insulin-dependent Type 2 diabetes (A1C 13.1) to losing over 100 pounds, lowering his A1C to 5.7, and stopping insulin after joining Twin Health. A CGM-guided, color-coded diet that emphasized whole foods and cut starch and processed foods—plus a regimen of twice-daily cardio and strength training—transformed his health. He even considered GLP-1 but chose to continue with nutrition and exercise because the changes were working. His wife, who lost 85 pounds, joined him on the journey, and the couple are now prepping for bodybuilding.

via TODAY.com|

#diabetes #diet #exercise

health12 days ago•1 min saved

MetALD: New Liver Disease Emerging from Obesity and Alcohol

MetALD—metabolic dysfunction and alcohol-associated liver disease—is a rising U.S. health concern as obesity and diabetes intersect with heavy drinking. It affects people with liver fat and metabolic risk factors who drink more than 10 drinks per week (women) or 15 (men); the share of Americans meeting these criteria has roughly doubled since 1990, with about 1 in 10 adults reporting overlapping heavy drinking and obesity. Doctors warn many cases may go undetected, particularly among younger people and women.

via statnews.com|

#alcohol #diabetes #health

science14 days ago•8 min saved

Ubiquitin Enables Direct Control of Glycogen, Paving New Diabetes Treatments

WEHI researchers report that ubiquitin can directly regulate glycogen, revealing a second on-demand pathway for stored sugar and a potential new route to treat diabetes, liver/heart diseases, and rare glycogen storage disorders using a novel NoPro-clipping technique.

via SciTechDaily|

#diabetes #glycogen #glycogen-storage-diseases

health14 days ago•5 min saved

Diabetes, a dog biscuit and a new life in a wheelchair

A Scottish woman with type 1 diabetes developed sepsis after stepping on a dog biscuit, leading to three emergency surgeries and the amputation of her right leg; now a full-time wheelchair user, she is rebuilding her life and urging better foot care and diabetes awareness.

via BBC|

#amputation #diabetes #health

health15 days ago•10 min saved

Gums as gateways: the surprising links between oral health and overall health

Gum disease and oral bacteria are increasingly linked to systemic health problems such as cardiovascular disease, stroke and diabetes, with inflammation and bloodstream spread playing key roles; while causality is complex, evidence suggests a real impact, and maintaining good oral hygiene (brushing twice daily, flossing) and reducing sugar intake is advised, though access to NHS dental care remains challenging for many.

via The Guardian|

#cardiovascular-disease #dementia #diabetes

food-and-drink22 days ago•11 min saved

Banana Ripeness Reveals Health Hacks: When to Eat Green, Yellow, or Brown

Bananas’ nutrition shifts with ripeness: underripe bananas are high in resistant starch for gut health and steady blood sugar; barely ripe to ripe balance fiber, minerals and sugar for energy; very ripe provide quick energy with higher sugar and lower fiber; overripe are best for baking or smoothies.

via HuffPost|

#bananas #blood-sugar #diabetes

health23 days ago•6 min saved

Weight-Loss Drugs Show Long-Term Heart Benefits Across High-Risk Patients

A meta-analysis of 11 cardiovascular outcome trials (over 90,000 patients) finds GLP-1 receptor agonists reduce major cardiovascular events and all-cause mortality by about 13% over an average follow-up of nearly three years, with benefits seen in high-risk groups including those with or without diabetes. While GI side effects (nausea, vomiting) are more common, no significant safety signals like pancreatitis or hypoglycemia emerged. The results suggest these obesity/diabetes drugs may play a broader role in cardiovascular risk reduction and could influence clinical practice and policy.

via SciTechDaily|

#cardiovascular-disease #diabetes #glp-1-receptor-agonists

health24 days ago•6 min saved

Vitamin D's emerging links to diabetes risk, brain biomarkers, and gut immunity

New studies suggest vitamin D may influence several chronic diseases: high-dose vitamin D (4,000 IU/day) reduced progression from prediabetes to type 2 diabetes in people with AC/CC variants of the vitamin D receptor gene, but had no benefit for others and excess doses carry risks; higher vitamin D levels in midlife were linked to lower tau protein, a biomarker for Alzheimer's, years later but not with beta-amyloid and the study had limitations; in inflammatory bowel disease, 12 weeks of vitamin D supplementation reduced gut inflammation and promoted a more balanced immune response (increasing IgA, decreasing IgG), indicating potential as an adjunct therapy. Overall, vitamin D is not a cure-all and results are preliminary, needing replication and careful medical supervision.

via Medical News Today|

#alzheimers-disease #diabetes #health