Tag

Immunotherapy

All articles tagged with #immunotherapy

health-and-medicine1 day ago•8 min saved

Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer

Researchers engineered ultrasmall silica nanoparticles (Cornell Prime dots) that target prostate tumors, trigger ferroptosis (iron-driven cell death), and remodel the tumor immune environment to a more active state. In mouse models of aggressive prostate cancer, these particles alone modestly improved survival, but when combined with immune checkpoint therapy they produced complete or near-complete remissions and indefinite survival in 4 of 10 mice, rising to 5 of 10 with an added CSF-1R blockade. The treatment localized to tumors with no observed toxicity in healthy tissues. If safety and efficacy translate to humans, this approach could move toward clinical trials as a multi-pronged cancer therapy that enhances immunotherapy effectiveness.

via ScienceDaily|

#ferroptosis #health-and-medicine #immunotherapy

health2 days ago•10 min saved

Cheap creatine shows promise in boosting cancer immunotherapy

UCLA researchers found creatine, a cheap sports supplement, can energize dendritic cells and enhance killer T-cell activity, potentially boosting cancer immunotherapy. In melanoma mouse models, daily creatine slowed tumor growth and increased immune cell activity within tumours, suggesting creatine could support immune-based cancer therapies, including dendritic-cell vaccines. However, findings are preclinical and not dietary or medical recommendations; patients should consult physicians before using supplements during cancer treatment.

via The Independent|

#cancer #cells #creatine

science2 days ago•86 min saved

Diet–Gut Allies Amplify Cancer Immunotherapy in Obesity

A Nature study shows that obesity-related immunotherapy responses are driven by the diet–gut microbiome axis rather than metabolic dysfunction alone. Using 12 mouse diet models, researchers found obesogenic diets foster a stable gut microbiota that can restore anti-PD-1 sensitivity after short diet changes or fecal microbiota transplantation from non-responders. Monocolonization with beneficial bacteria like Lactobacillus johnsonii, paired with an obesogenic diet, enhanced tumor regression via microbiota-derived aromatic amino acid metabolites. In human-to-mouse FMT, high-BMI donors boosted ICI efficacy versus normal-BMI donors, and an obesogenic diet could restore sensitivity after FMT from a non-responder. The work suggests diet–microbiome synergy could be leveraged to improve ICI outcomes and guide FMT-based strategies.

via Nature|

#diet #immunotherapy #microbiome

science3 days ago•242 min saved

Creatine could boost cancer immunity, UCLA study finds

UCLA researchers found that creatine helps energize dendritic cells, which present tumor fragments to T cells, slowing melanoma growth in mice and potentially supporting immunotherapies; the study, published in iScience, does not yet justify dietary changes for patients and human trials are needed.

via AOL.com|

#cancer #creatine #dendritic-cells

science6 days ago•6 min saved

Engineered Immune Progenitors Enable Scalable CAR-M Cancer Therapy

Researchers engineered macrophage progenitor cells to self-renew and differentiate into macrophages for CAR-M therapy. Using GMPs, they produced a persistent immune cell supply that spread through the body in mice and slowed both blood cancers and solid tumors, offering a scalable alternative to CAR-T for broader cancer immunotherapy.

via ScienceAlert|

#cancer #car-m #granulocyte-monocyte-progenitors

science8 days ago•5 min saved

Immunotherapy Sparks Hair Color Comeback, Hinting at Grey Hair Reversal

Emerging reports suggest grey hair might be reversible: cancer patients treated with immunotherapy drugs showed hair pigment returning, possibly by reactivating melanocyte stem cells. University of Alabama researchers are pursuing this for hair pigment, but no human trials exist yet, so practical applications are months away. Meanwhile, market supplements claim repigmentation with limited evidence.

via New York Post|

#greying-hair #hair-pigment #immunotherapy

health-and-medicine11 days ago•8 min saved

Engineered immune progenitors offer endless supply of cancer-fighting cells

USC researchers developed a stem-cell–inspired method to expand granulocyte-monocyte progenitors (GMPs), enabling long-term self-renewal and genetic engineering to produce macrophages that can target cancer. Engineered GMPs carrying a CAR and an additional immune-activating signal demonstrated tumor-fighting activity and sustained production of immune cells in mice, suggesting a scalable, off-the-shelf cellular immunotherapy with potential applications beyond cancer.

via ScienceDaily|

#car #granulocyte-monocyte-progenitors #health-and-medicine

health15 days ago•2 min saved

Morning Immunotherapy Effect in Question as Key Study Is Retracted

Nature Medicine retracted a Chinese trial that claimed morning administration of immunotherapy yielded dramatic cancer benefits, citing concerns about data integrity; the ruling undermines the reported timing advantage and leaves clinicians cautious about changing practice.

via The New York Times|

#cancer #health #immunotherapy

business15 days ago•3 min saved

A Bold Immunotherapy Bet That Reshaped Cancer Care

Dr. Israel Lowy, who helped pioneer cancer immunotherapy starting with AIDS work, led early anti-PD-1/PD-L1 and anti-CTLA-4 trials and played a key role in the development of blockbuster therapies like Keytruda and Opdivo. Despite skepticism and recent trial setbacks, he emphasizes ongoing exploration of the tumor microenvironment and strategic biotech deals (e.g., Regeneron–CytomX, Parabilis) to combine immune and targeted therapies, reflecting a long‑term shift in biotech innovation and cancer care.

via Fierce Biotech|

#business #cancer #ctla-4

health16 days ago•2 min saved

Brain Cancer Vaccine Yields Long-Term Survival in About a Quarter of Patients

A UCLA-led immunotherapy approach for glioblastoma exposes a patient’s white blood cells to tumor cells outside the brain, then reinfuses them as a vaccine. From 2003–2019 trials, 331 patients received the vaccine and 20–25% survived years longer, with 2023 JAMA Oncology results prompting further study of why some patients respond. Researchers are examining biomarkers like MGMT methylation and the gut microbiome to predict benefit. The work, led by Dr. Linda Liau, has earned recognition in medicine and reflects her personal drive born from family experience with brain cancer.

via Brown Alumni Magazine|

#brain-tumor #cancer-vaccine #glioblastoma

science16 days ago•8 min saved

GABA-Driven Immunosuppression Sparks Female-Specific GBM Growth

Researchers at the University of Miami found that glioblastoma grows via a female-specific mechanism in which the neurotransmitter GABA reprograms granulocytic myeloid-derived suppressor cells (MDSCs) to become more immunosuppressive, promoting tumor growth only in females. Blocking GABA receptors in female models dismantled this immune shield and improved survival, with human tumor samples showing higher GABA and GABA receptor levels in female granulocytic MDSCs. The findings suggest sex-specific immunotherapy approaches for brain cancer and potential broader applications to other tumors that recruit MDSCs.

via Neuroscience News|

#gaba #glioblastoma #immunotherapy

science16 days ago•13 min saved

When cancer hides MHC I, NK cells may strike back

For decades, MHC class I was seen as the marker used by T cells to detect cancer, but tumors that downregulate MHC I evade T cells while potentially exposing themselves to natural killer (NK) cells that detect 'missing self.' NK cells are inhibited by MHC I through receptors like KIRs, so loss of MHC I can lift that brake, creating a vulnerability. In practice, tumors face barriers to NK cell infiltration and can become exhausted, making responses inconsistent. Researchers are pursuing NK cell–based therapies and cytokine strategies to exploit MHC I loss, particularly in cancers resistant to checkpoint inhibitors, with the goal of turning this paradox into a new therapeutic avenue while continuing to tackle delivery and safety challenges.

via Space Daily|

#cancer-immunology #immunotherapy #mhc-i

health18 days ago•5 min saved

NHS rolls out teplizumab to delay the onset of type 1 diabetes

England and Wales will offer teplizumab, the first treatment shown to delay onset of type 1 diabetes by around three years, given as 14 days of IV infusions before symptoms. NICE estimates about 1,100 adults and children could be eligible in the first year, with a confidential NHS discount on the roughly £150,000-per-course price. The drug requires evidence of pre-symptomatic immune attack on the pancreas; routine UK screening remains unavailable. Scotland and Northern Ireland have separate processes, with Scotland’s SMC expected to issue advice in 2027.

via BBC|

#health #immunotherapy #nhs

health-and-medicine18 days ago•6 min saved

High-Dose Niacin Shows Promise Against Aggressive Brain Cancer

University of Calgary researchers are testing high-dose vitamin B3 (niacin) alongside standard glioblastoma treatment to revive immune cells and attack tumors. In an early Phase I/II trial, 24 patients showed a six-month progression-free survival of 82% — about 28% better than earlier studies — suggesting niacin could boost immune response against this deadly brain cancer, though safety at high doses remains a key consideration as the study continues toward 48 participants by late 2026/early 2027.

via ScienceDaily|

#clinical-trial #glioblastoma #health-and-medicine

health18 days ago•42 min saved

CAR-T Lupus Breakthrough Drives Remission and Cure-Hope in Trial

A UK trial at University College London Hospital using CAR T-cell therapy to treat lupus nephritis showed remission in five of nine patients within three months, with remissions lasting through an 11-month follow-up, including a patient who fulfilled a skiing dream—an advance that researchers say could herald a lupus cure if confirmed in larger studies.

via Good News Network|

#car-t-cell-therapy #health #immunotherapy