Tag

Immunotherapy

All articles tagged with #immunotherapy

health1 day ago•14 min saved

Vaccines May Slow Dementia: A Welsh Natural Experiment Sparks New Hope

A 2013 Welsh, age-based shingles-vaccine rollout created a natural experiment showing people offered the vaccine were about 20% less likely to develop dementia, with some data suggesting vaccines might also slow progression in those already with dementia. Across multiple vaccines (influenza, BCG, shingles, and others) there are growing links to lower dementia risk, likely via trained immunity that broadens immune protection. While promising, dementia vaccines face past trial failures and require coordinated, long-term research and funding before they can become a widespread preventive strategy.

via BBC Science Focus Magazine|

#dementia #health #immunotherapy

health1 day ago•3 min saved

Gut Microbiome Transplants Show Early Hints of Peanut Allergy Tolerance

A small Boston Children’s Hospital study used donor gut bacteria delivered via “poop pills” to people with severe peanut allergies; several participants showed increased tolerance to peanuts months later, especially after antibiotics to clear existing gut microbes. The results suggest a microbiome-based pathway affecting immune tolerance, with follow-up trials exploring teen capsule transplants and combining microbiome therapy with peanut immunotherapy.

via LiveNOW from FOX|

#bile-salts #fecal-transplant #health

healthcare1 day ago•3 min saved

Moderna and Merck claim a hard-won melanoma vaccine breakthrough

Topline results from a large trial show Moderna and Merck’s cancer vaccine, intismeran autogene, reduced recurrence or spread of surgically removed melanoma, signaling a milestone after years of doubt and pandemic-related hurdles—though some scientists urge waiting for fuller data and longer follow-up before declaring a definitive breakthrough.

via STAT|

#cancer-vaccine #healthcare #immunotherapy

health2 days ago•20 min saved

Melanoma vaccine trial signals transformative path for cancer care

The Washington Post profiles Mark Orwig and other melanoma patients in a Moderna/M Merck trial testing an mRNA-based cancer vaccine. Early results suggest the vaccine could prevent cancer recurrence after surgery, a finding experts say could transform cancer care and accelerate FDA approval, despite participants experiencing side effects and a tough recovery.

via The Washington Post|

#cancer #clinical-trials #health

health2 days ago•204 min saved

Breakthrough Cancer Vaccine Gains Ground, but Misinformation Could Stall It

A personalized mRNA cancer vaccine from Moderna and Merck reduced melanoma recurrence when combined with Keytruda in a late-stage trial, signaling a potential new era in cancer prevention and treatment, but wide-spread misinformation about mRNA technology—including the ‘turbo cancer’ narrative—could undermine public trust and slow adoption of these advances.

via CNN|

#cancer-vaccines #health #immunotherapy

science4 days ago•40 min saved

KRAS-Targeted Drug Sparks Immune Defense to Prevent Pancreatic Cancer in High-Risk People

Johns Hopkins researchers report that an experimental KRAS-targeting drug was safe in a phase 1 trial of 20 people at high risk for pancreatic cancer and successfully activated KRAS-specific T-cells in 90% of participants, with immune responses persisting for about two years; while no cancers or high-risk lesions progressed during follow-up, the small study was not designed to prove prevention.

via Good News Network|

#clinical-trial #immunotherapy #kras

health-and-medicine5 days ago•7 min saved

Probiotic Bacteria Forge Localized Immunotherapy for Pancreatic Cancer

Engineered Bifidobacterium longum delivers SumIL-2 directly into pancreatic tumors to activate cancer-fighting T cells, slowing tumor growth in animal studies; the effect improves when combined with chemotherapy, radiation, or anti-PD-L1 immunotherapy, and hinges on the tumors’ low-oxygen microenvironment to localize treatment. Human safety and delivery method remain to be tested.

via Science Daily|

#bacteria-delivery #health-and-medicine #immunotherapy

health6 days ago•4 min saved

Personalised mRNA vaccine plus Keytruda halts melanoma relapse in trial

A phase 3 trial of a personalised mRNA vaccine (Intismeran) given with Keytruda after melanoma surgery extended disease-free time in over 1,000 high-risk patients. While the interim results are promising, they have not yet been peer-reviewed and regulatory approval is still required before NHS rollout.

via BBC|

#health #immunotherapy #melanoma

science6 days ago•6 min saved

Hidden Skull Immune Hubs May Help Fight Brain Cancer

Scientists have identified a skull bone marrow niche that acts as a brain-focused immune hub, with channels linking brain tissue to skull lymphoid structures. In mouse glioma models, boosting these skull hubs improved anti-tumor responses and survival, hinting at a potential, less invasive therapy for brain cancer—pending confirmation that humans have similar structures and translating the approach to clinics.

via ScienceAlert|

#brain-cancer #glioma #immunotherapy

health6 days ago•5 min saved

Personalized mRNA vaccine plus Keytruda shows promising Phase 3 melanoma results

Moderna and Merck report that adding the patient-specific mRNA cancer vaccine intismeran (mRNA-4157) to Merck’s Keytruda significantly extended recurrence-free and distant metastasis-free survival versus Keytruda alone in a Phase 3 trial of 1,137 melanoma patients. Interim results suggest meaningful benefit, with mature overall-survival data still pending; five-year Phase 2 data had previously shown substantial risk reductions. Full details will be presented at an upcoming conference.

via Ars Technica|

#health #immunotherapy #melanoma

health6 days ago•2 min saved

Moderna-Merck mRNA vaccine shows promise in delaying melanoma recurrence

Moderna and Merck report interim Phase 3 results suggesting their personalized mRNA cancer vaccine Intismeran, used with Keytruda after melanoma surgery, may delay cancer recurrence in high-risk patients; data have not yet been peer‑reviewed and will be presented at a medical meeting and shared with regulators as the trial continues to assess overall survival.

via NBC News|

#health #immunotherapy #intismeran

health12 days ago•7 min saved

Gut microbiome transplant offers early hope for peanut allergy treatment

In a phase 1, open-label trial at Boston Children’s Hospital, 15 adults with peanut allergies received fecal microbiota transplants to reset the gut microbiome. Ten participants received FMT capsules and five later got a transplant after antibiotics; about 40% achieved meaningful, durable increases in peanut tolerance (up to 300–600 mg, with one participant tolerating 1,043 mg) lasting at least four months. Side effects were minor and no major adverse events occurred. While promising, larger randomized trials are needed and FMT is not yet ready for clinical use; mouse studies suggested two Bacteroides species may drive the protective effect.

via ScienceAlert|

#clinical-trial #fecal-microbiota-transplant #gut-microbiome

science13 days ago•43 min saved

In vivo CRISPR screens reveal GPCR–GNAS axis as a brake on T cell therapy in solid tumors

Nature reports a scalable in vivo platform for genome-wide CRISPR screens in human T cells within solid tumors. Two screens found that GPCR signaling via the P2RY8–Gα13 axis limits T cell tumor infiltration, while GNAS (Gαs) drives intratumoral T cell dysfunction. Knocking out GNAS enhances T cell fitness and antitumor efficacy across multiple CAR/TCR models, and combining P2RY8 and GNAS edits yields even better tumor control, enabling systematic genetic improvements for solid-tumor T cell therapies.

via Nature|

#gnas #gpcr #immunotherapy

health15 days ago•5 min saved

Vaccines Aim to Halt Lynch Syndrome–Driven Colon Cancer Before It Starts

Researchers are developing vaccines that train the immune system to recognize and attack Lynch syndrome–related precancers, potentially preventing colorectal cancer in high-risk individuals; early trials (Nouscom, with follow-ons from Moderna and ImmunityBio) show the approach can boost tumor-fighting T cells and reduce precancerous growths, with larger U.S. and Britain studies planned.

via ABC7 Los Angeles|

#colon-cancer #health #immunotherapy

health17 days ago•201 min saved

Vaccines aim to stop Lynch syndrome–driven colon cancer before it starts

Researchers are testing vaccines designed to train the immune system to recognize and destroy precancerous Lynch syndrome–driven cells, with early trials showing reduced precancerous polyps and polyp-free colonoscopies in some participants. Several vaccines are in development (Nouscom in the US/UK, Moderna via Oxford, ImmunityBio) aiming to prevent colorectal cancer before it starts, potentially reducing the need for yearly colonoscopies for high-risk individuals. Results are early but promising for those with inherited cancer risk and their families.

via CNN|

#cancer-vaccines #colon-cancer #genetics