
Vitamin D Deficiency May Amplify Postoperative Pain After Mastectomy
Researchers in Egypt followed 184 breast cancer patients undergoing mastectomy and found those with vitamin D deficiency (<30 nmol/L) reported more moderate-to-severe pain in the first 24 hours and used more opioids—about 112 mg more tramadol postoperatively and 8 μg more fentanyl intraoperatively—than those with sufficient vitamin D; the study cannot prove cause-and-effect and did not measure inflammatory markers, but suggests preoperative vitamin D supplementation may help reduce postoperative pain, pending further research.













