Tag

Brca2

All articles tagged with #brca2

health1 month ago•5 min saved

Dog's breast cancer mirrors owner's battle as both beat the disease

A UK woman battling a second breast cancer diagnosis adopted Dolly in 2018 for support; years later Dolly was diagnosed with breast cancer and underwent a mastectomy, with the cancer described as low-grade and requiring no further treatment, and both dog and owner are now cancer-free. The owner carries a BRCA2 gene mutation and also had a double mastectomy, illustrating the deep bond with a pet that can accompany and comfort patients through cancer treatment.

via Fox News|

#brca2 #breast-cancer #dog-cancer

health2 months ago•81 min saved

BRCA2 Germline Variants and RB1 Loss Drive CDK4/6 Resistance in Breast Cancer

A large clinicogenomic analysis of 5,881 breast cancer patients shows germline BRCA2 mutations predispose tumors to acquire RB1 loss under CDK4/6 inhibitor pressure, aided by baseline RB1 hemizygosity and ongoing homologous recombination deficiency. This RB1 loss drives resistance to frontline CDK4/6 inhibitors, while PARP inhibitors outperform CDK4/6 inhibitors across models and data. The study proposes prioritizing PARP inhibition for gBRCA2 carriers to intercept RB1‑loss trajectories and delay resistance, and provides a predictive framework using pre-treatment germline/somatic context and mutational signatures to forecast resistance trajectories.

via Nature|

#brca2 #cdk46-inhibitors #health

health1 year ago•6 min saved

Innovative Breast Cancer Treatment Achieves 100% Survival Rate

A new pre-surgery treatment combining chemotherapy and the targeted drug olaparib, with a carefully timed 48-hour gap, has achieved a 100% survival rate in a clinical trial for aggressive inherited breast cancers linked to BRCA mutations, potentially revolutionizing treatment approaches.

via SciTechDaily|

#brca1 #brca2 #breast-cancer

health1 year ago•1 min saved

"18th Century Scots Island Family Linked to Cancer Risk Genes"

A Shetland woman, Christine Glaser, discovered her breast cancer through the Viking Genes research project, which identified a BRCA 2 gene variant in her family, leading to early and successful treatment.

via BBC.com|

#brca2 #cancer #genetics

health2 years ago•3 min saved

"New Drug Offers Hope for Breast Cancer Prevention in Women with 'Angelina Jolie Gene'"

A University of Cambridge study suggests that prescribing existing drugs to healthy women with faulty BRCA1 and BRCA2 genes, which increase the risk of developing breast cancer, could prevent the disease by targeting exhausted immune cells. This breakthrough could potentially reduce the need for mastectomies and provide a preventative treatment option. The study's Human Breast Cell Atlas identified these exhausted immune cells, opening up possibilities for using immunotherapy drugs preventatively. Further research and clinical trials are needed to confirm the effectiveness of this approach.

via Yahoo! Voices|

#brca1 #brca2 #breast-cancer