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Medicine And Drugs

All articles tagged with #medicine and drugs

medicine-and-drugs1 month ago•111 min saved

Psilocybin May Shield Nerves From Chemotherapy, Mouse Study Suggests

A mouse study published in Science found that psilocybin, given before chemotherapy, can prevent chemotherapy-induced peripheral neuropathy by preserving mitochondrial trafficking and ATP production in nerve endings. The protective effect relies on the serotonin receptor 5-HT2A, and a non-hallucinogenic 5-HT2A activator also provided protection. Human trials have not yet proven efficacy, though researchers plan to move toward clinical testing.

via Live Science|

#5-ht2a #chemotherapy #medicine-and-drugs

medicine-and-drugs1 month ago•138 min saved

Metformin’s core mechanism revealed: gut mitochondria drive its glucose-lowering effect

A Nature Metabolism study shows metformin lowers blood sugar primarily by inhibiting mitochondrial complex I in intestinal cells, causing those cells to burn more glucose via glycolysis. Liver-level action is less likely since liver concentrations of metformin are low. In mice engineered with a backup intestinal enzyme, the drug’s glucose-lowering effect dropped about 80%, suggesting intestinal complex I inhibition as the main acute mechanism, though researchers caution about translating findings to humans and acknowledge additional targets may exist.

via Live Science|

#complex-i #diabetes #intestines

medicine-and-drugs3 months ago•92 min saved

Peptides craze meets caution: unregulated injections spark safety and regulatory questions

A wellness-driven surge in peptide injections touted for healing, recovery, and muscle-building rests on limited clinical evidence and carries safety risks. In 2023 the FDA banned production of several peptides by compounding pharmacies due to safety concerns and impurities, and the agency does not approve such compounds. US policy discussions about legalizing broader compounding could boost access but also risk, as product quality and dosing vary and most data come from animal studies. Experts urge caution and emphasize that rigorous human trials are still needed to establish true benefits and safety.

via Live Science|

#fda #gray-market #medicine-and-drugs