
Endoscopic gut reset may lock in GLP-1 weight loss after stopping meds
A minimally invasive endoscopic procedure called duodenal mucosal resurfacing may help people maintain weight loss after discontinuing GLP-1 diabetes/weight-loss drugs. In a six‑month follow‑up of 45 participants (29 treated, 16 sham) who had at least 15% weight loss on tirzepatide, the procedure group regained about seven pounds and kept over 80% of their drug‑induced weight loss, while the sham group regained more, suggesting a durable metabolic reset observed at Digestive Disease Week 2026.
