Tag

Nanobody

All articles tagged with #nanobody

health18 days ago•2 min saved

MoonLake's nanobody delivers strong phase 3 results in psoriatic arthritis

MoonLake Immunotherapeutics reported positive topline phase 3 IZAR-1 data for biologic‑naïve psoriatic arthritis patients treated with sonelokimab, with week‑16 endpoints meeting across ACR50 (42.1%), ACR20 (66.5%), minimal disease activity (41.2%), and PASI90 in patients with skin involvement (61%), though there is no active comparator arm and topline results will be followed by blinded analyses with full data due in H1 2027; IZAR-2 and other IL-17 nanobody programs are ongoing.

via Fierce Biotech|

#health #moonlake-immunotherapeutics #nanobody

science1 year ago•61 min saved

Nanobody Targets HSV Glycoprotein B to Neutralize Herpes Viruses

Researchers developed a prefusion-specific nanobody that neutralizes HSV-1 and HSV-2 by binding to glycoprotein B, preventing its conformational change necessary for viral fusion, with detailed structural insights provided by cryo-EM.

via Nature|

#glycoprotein-b #hsv-1 #hsv-2

health3 years ago•2 min saved

"Promising Nanobody Unveiled as Potential Retinitis Pigmentosa Therapy"

Scientists from the University of California, Irvine, have discovered a nanobody that may lead to a treatment for Retinitis Pigmentosa (RP), a group of inherited eye diseases that cause vision loss. The nanobody targets the Rhodopsin molecule, a key light-sensing molecule in the retina, and can halt its photoactivation process. The nanobodies have shown high specificity and can recognize the target Rhodopsin extracellularly, potentially allowing for the development of gene therapies for RP. The researchers aim to improve the nanobodies' ability to recognize Rhodopsin from other species and resolve the key intermediate states of Rhodopsin for further study.

via News-Medical.Net|

#health #nanobody #research