All articles tagged with #paramutation
Researchers in mice report that about 7% of inherited DNA methylation patterns escape Mendel’s rules, revealing non-Mendelian epigenetic inheritance and even a mammalian paramutation, suggesting that epigenetic marks can be transmitted across generations and influence traits without changing DNA sequence.
A federally funded mouse study finds that about 7% of inherited epigenetic patterns do not follow Mendel’s laws, uncovering additional imprinting events, emergent inheritance patterns that can’t be traced to either parent, and a rare mammalian paramutation in Capn11. The findings suggest epigenetic marks can be transmitted and even arise across generations, potentially influencing disease risk, and were mapped using long-read sequencing across three mouse generations.
Mouse study reveals inherited DNA methylation patterns that break Mendel’s rules, identifying 522 non-sex-chromosome cases across three generations (~7%), plus emergent patterns and probable paramutation, suggesting inheritance can be shaped by epigenetic marks beyond DNA sequence and may influence trait transmission and disease risk.