Epigenetic Echoes Reveal Non-Mendelian Inheritance in Mammals
A federally funded mouse study finds that about 7% of inherited epigenetic patterns do not follow Mendel’s laws, uncovering additional imprinting events, emergent inheritance patterns that can’t be traced to either parent, and a rare mammalian paramutation in Capn11. The findings suggest epigenetic marks can be transmitted and even arise across generations, potentially influencing disease risk, and were mapped using long-read sequencing across three mouse generations.
