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Dna Methylation

All articles tagged with #dna methylation

Daily multivitamin slows ageing markers in older adults, study suggests
health1 month ago

Daily multivitamin slows ageing markers in older adults, study suggests

A two-year, randomized COSMOS trial found that taking a daily multivitamin slowed certain epigenetic clocks of ageing in people around 70, reducing biological age by about four months versus non-users; the effect was more pronounced in individuals with accelerated ageing and was observed in two of five DNA methylation clocks linked to mortality risk. While promising, the authors emphasize the effects are small and do not yet imply improved clinical outcomes.

via Nature|
#ageing#cosmos-study#dna-methylation
health2 months ago

Cambridge blood test could spark UK prostate cancer screening

Researchers at the University of Cambridge are developing a DNA methylation–based blood test that could not only detect prostate cancer but also indicate its aggressiveness and need for treatment, potentially underpinning a UK national screening programme. PSA tests currently used for screening are unreliable and UK advisers have urged targeted screening rather than broad population testing; a more accurate blood test could broaden screening, reduce unnecessary biopsies, and guide treatment decisions. The team plans UK clinical trials within 18–24 months and states the new test would complement, not replace, existing PSA testing. Prostate cancer is the UK’s most common cancer with about 12,000 deaths annually.

via The Telegraph|
#dna-methylation#health#prostate-cancer
CRISPR breakthrough activates genes without DNA cuts
science3 months ago

CRISPR breakthrough activates genes without DNA cuts

Scientists at UNSW Sydney have developed a new CRISPR-based epigenetic editing technique that can turn genes on without cutting DNA, by removing chemical methyl groups that silence genes. This approach could lead to safer gene therapies for conditions like Sickle Cell disease, as it avoids the risks associated with DNA strand breaks. The research demonstrates that methylation directly controls gene activity and opens new possibilities for treating genetic disorders by reactivating silenced genes.

via ScienceDaily|
#crispr#dna-methylation#epigenetic-editing
Scientists Discover Why Aging Gut Genes Go Silent
science3 months ago

Scientists Discover Why Aging Gut Genes Go Silent

Scientists discovered a specific epigenetic drift called ACCA that accumulates in aging gut stem cells, leading to gene silencing linked to inflammation and cancer risk. This process is influenced by iron metabolism and inflammation but can potentially be slowed or reversed by restoring iron levels or activating Wnt signaling, offering new insights into intestinal aging and cancer prevention.

via SciTechDaily|
#cancer-risk#dna-methylation#epigenetic-aging
CRISPR Innovation Promises New Era in Genetic Disease Therapy
science3 months ago

CRISPR Innovation Promises New Era in Genetic Disease Therapy

Researchers at UNSW Sydney have developed a safer CRISPR-based epigenetic editing technique that can switch genes on and off without cutting DNA, offering promising new treatments for genetic diseases like Sickle Cell by reactivating silenced genes through removal of methyl groups, potentially reducing risks associated with traditional gene editing.

via SciTechDaily|
#crispr#dna-methylation#epigenetic-editing