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Epigenetics

All articles tagged with #epigenetics

Prime editing maps essential histone H3 lysines in mammalian cells
science3 days ago

Prime editing maps essential histone H3 lysines in mammalian cells

Researchers developed a high-throughput CRISPR prime-editing platform to mutate all canonical histone H3 genes in mouse embryonic stem cells and map lysine requirements for cell fitness. The screen pinpointed key residues (H3K4, H3K9, H3K14, H3K18, H3K79) whose disruption reduces fitness, with H3K56 playing a conserved role in genome stability; combinatorial edits reveal functional crosstalk (for example, H3K27R + H3K36R impairs self-renewal and transcription). The approach can occasionally generate kilobase-scale deletions in histone clusters when nicking is used, but careful screening yields clean clones, establishing a functional map of H3 lysines and a versatile toolkit for studying chromatin regulation in mammals.

via Nature|
#crispr#epigenetics#histone-h3
Are Younger Cancers Fueled by Faster Biological Aging?
health3 days ago

Are Younger Cancers Fueled by Faster Biological Aging?

Young adults are seeing rising colorectal and other cancers even as overall rates fall. Research from Team Prospect and Yin Cao links accelerated aging—measured with aging clocks like Horvath’s epigenetic clock and GrimAge—to a higher risk of cancer in those born after 1965. The work suggests biology may age faster in some people, potentially driving earlier, more aggressive cancers, and it highlights efforts to slow aging with therapies targeting senescent cells, NAD+, and other approaches. Meanwhile, cancer screening is evolving, with earlier colonoscopy recommendations (start at 45 for average risk) and new blood-based or imaging screening methods supplementing traditional tests.

via Men's Health|
#aging#biomarkers#cancer
Air pollution may reprogram sperm DNA, raising fertility concerns
health5 days ago

Air pollution may reprogram sperm DNA, raising fertility concerns

A large fertility study following over 2,000 men links exposure to outdoor pollutants (notably ozone and nitrogen dioxide) during sperm development to subtle DNA methylation changes in sperm that regulate gene activity. Researchers identified 39 pollution-associated DNA changes, including in the GNAS gene, suggesting a potential mechanism by which air pollution could affect fertility. However, a direct link to infertility has not been proven, and further work is needed to confirm clinical significance.

via The Guardian|
#air-pollution#environmental-health#epigenetics
Diet, Exercise, and Daily Vitamins Linked to Slower Biological Aging
health20 days ago

Diet, Exercise, and Daily Vitamins Linked to Slower Biological Aging

Three studies tie common lifestyle choices to slower biological aging: a 2-year trial found that daily Centrum Silver multivitamins (with cocoa flavanols) modestly slowed aging as measured by epigenetic clocks; a large study of 24,576 adults found higher midlife cardiorespiratory fitness linked to longer health span and life span; and a 4-week dietary intervention favoring plant-based foods and complex carbohydrates reduced the gap between biological age and chronological age as measured by the Klemera-Doubal method, suggesting diet and activity can meaningfully affect aging markers in older adults.

via Healthline|
#aging#epigenetics#exercise
Five Simple Rules for Longevity from an 85-Year-Old Italian Matriarch
health-and-wellness1 month ago

Five Simple Rules for Longevity from an 85-Year-Old Italian Matriarch

Stanford epigenetics researcher Dr. Lucia Aronica highlights her mother Livia’s five rules for a long, happy life: eat slowly and with joy using Mediterranean foods; move naturally rather than just in the gym; cultivate close relationships and community; wake up each day with a sense of purpose; and let everyday pleasures guide you. Supported by research on epigenetics, social ties, and positive emotions, true longevity blends biology with psychology and social well-being rather than chasing biomarkers.

via CNBC|
#epigenetics#health-and-wellness#longevity
Dad's Preconception Drinking Alters Offspring Mitochondria, Study Finds
science1 month ago

Dad's Preconception Drinking Alters Offspring Mitochondria, Study Finds

Texas A&M researchers, backed by a $2.9 million NIH grant, are investigating how a father's alcohol consumption before conception can imprint non-genetic signals in sperm that disrupt offspring mitochondrial function, potentially leading to birth defects, chronic disease, and accelerated aging, while exploring interactions with maternal exposure and implications for other environmental stressors.

via Neuroscience News|
#epigenetics#fetal-alcohol-spectrum-disorders#mitochondria
Chlorpyrifos: new review finds broad, multi-system toxicity
science1 month ago

Chlorpyrifos: new review finds broad, multi-system toxicity

A comprehensive April 2026 review of nearly 300 studies finds chlorpyrifos causes widespread harm beyond its well-known neurotoxic effects, including damage to the brain, hormones, liver, gut microbiome, muscles, reproductive organs, and bones, plus DNA damage and lasting epigenetic changes. Some adverse effects occur at exposure levels below current safety thresholds, with fetuses and young children especially vulnerable. Regulators may not fully capture these risks in testing, prompting calls for independent research, stronger protections for pregnant people and children, and a reassessment of industry-sponsored studies as the EPA reevaluates remaining uses of the pesticide.

via U.S. Right to Know|
#chlorpyrifos#epigenetics#neurotoxicity
Birth-Time Epigenetics and Gut Bacteria Linked to Autism and ADHD Risk, Some Microbes May Offer Protection
health-and-medicine1 month ago

Birth-Time Epigenetics and Gut Bacteria Linked to Autism and ADHD Risk, Some Microbes May Offer Protection

A birth-time epigenetic setting appears to steer gut microbiome development in infancy, and specific epigenetic–microbiome combinations by age three are associated with autism and ADHD signs; certain bacteria, notably Lachnospira pectinoschiza and Parabacteroides distasonis, may be protective, suggesting future probiotic strategies while factors like delivery mode, antibiotics, siblings, and breastfeeding shape early microbial communities.

via ScienceDaily|
#adhd#autism#epigenetics
Gene body methylation acts as a genome defense and enables heritable regulatory variation in a cnidarian
epigenetics1 month ago

Gene body methylation acts as a genome defense and enables heritable regulatory variation in a cnidarian

In the cnidarian Nematostella vectensis, gene body methylation (gbM) marks stably expressed genes and is not a driver of dynamic transcription. Loss of 5mC via a DNMT1 inhibitor or DNMT1/UHRF1 morpholinos leads to global demethylation, widespread chromatin opening, and ectopic intragenic transcription, including activation of young transposons. Importantly, methylation is selectively re-established in the germline and is not globally reset after fertilization, allowing heritable aberrant methylation states and generating regulatory variation across generations—supporting gbM as an ancient genome defense in animals.

via Nature|
#epigenetic-inheritance#epigenetics#gbm
Epigenetic Echoes Reveal Non-Mendelian Inheritance in Mammals
science1 month ago

Epigenetic Echoes Reveal Non-Mendelian Inheritance in Mammals

A federally funded mouse study finds that about 7% of inherited epigenetic patterns do not follow Mendel’s laws, uncovering additional imprinting events, emergent inheritance patterns that can’t be traced to either parent, and a rare mammalian paramutation in Capn11. The findings suggest epigenetic marks can be transmitted and even arise across generations, potentially influencing disease risk, and were mapped using long-read sequencing across three mouse generations.

via ScienceDaily|
#epigenetics#imprinting#inheritance
Epigenetic twists: hundreds of inherited DNA patterns defy Mendelian genetics
health1 month ago

Epigenetic twists: hundreds of inherited DNA patterns defy Mendelian genetics

Mouse study reveals inherited DNA methylation patterns that break Mendel’s rules, identifying 522 non-sex-chromosome cases across three generations (~7%), plus emergent patterns and probable paramutation, suggesting inheritance can be shaped by epigenetic marks beyond DNA sequence and may influence trait transmission and disease risk.

via The Brighter Side of News|
#dna-methylation#epigenetics#gene-regulation
A 117-Year-Old's Biology Challenges Our View of Aging
science1 month ago

A 117-Year-Old's Biology Challenges Our View of Aging

Scientists studied Maria Branyas, the oldest verified person, through genome, proteome, epigenome, metabolome, transcriptome, and microbiome analyses. They found a paradox: signs of advanced aging (short telomeres, pro‑inflammatory immunity, clonal hematopoiesis) coexisted with protective traits (genetic variants linked to immune fitness and brain/heart protection, favorable lipid metabolism, very low inflammation, and a gut microbiome rich in Bifidobacterium). Epigenetic clocks suggested her cells behaved younger than her years by as much as about 23 years in some measures, implying aging and disease can be decoupled at the molecular level. The study warns that extreme longevity likely requires a rare genetic-lifestyle-environment blend and points to biomarkers for healthy aging as potential strategies to extend life expectancy.

via SciTechDaily|
#aging#epigenetics#longevity