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Pd 1xvegf

All articles tagged with #pd 1xvegf

health2 days ago•7 min saved

Ivonescimab+chemo extends survival in first-line squamous NSCLC at ASCO

Akeso’s ivonescimab, a PD-1xVEGF bispecific, plus chemotherapy significantly extended overall survival in first-line, untreated squamous NSCLC in the Harmoni-6 trial, cutting death risk by 34% with a median OS of 27.9 months vs 23.7 months (p=0.0017) versus Tevimbra-chemo. The interim China-only ASCO presentation showed benefit across PD-L1–negative and –positive patients, but experts caution the follow-up is immature and point to safety signals and trial eligibility criteria that may limit global applicability, signaling a need for further studies.

via Fierce Pharma|

#harmoni-6 #health #ivonescimab

business1 month ago•6 min saved

Merck's PD-1xVEGF bispecific MK-2010 shows early NSCLC signals in China trial

Merck reported first clinical data from its PD-1xVEGF bispecific MK-2010 in a Chinese phase 1/2 NSCLC trial, showing unconfirmed ORRs of 55% in treatment-naïve PD-L1-positive patients at 20 mg/kg every three weeks and 44% at 30 mg/kg, with lower responses in previously treated patients. Across backfill cohorts (n=72) the safety profile included dose-limiting toxicities like grade 3 proteinuria and hemoptysis, several bleeding events, and deaths in higher-dose arms, though the maximum tolerated dose has not been reached. Results are early, from small cohorts, and Merck has not disclosed phase 3 plans, as rivals advance multiple PD-(L)1xVEGF programs; more data are needed to define MK-2010's potential role.

via Fierce Biotech|

#business #clinical-trial #immunotherapy