Tag

Clinical Trial

All articles tagged with #clinical trial

science2 days ago•36 min saved

iPSC-derived stem cells show strong heart-function gains in a Chinese trial

In a small Chinese study, 10 patients with severe heart failure received injections of their own induced pluripotent stem cells differentiated into heart muscle cells. Over 12 months, 9 of the 10 showed significant improvements in cardiac function and six-minute walk distance compared with a control group that underwent bypass surgery; one control patient died eight months after surgery. Some patients experienced temporary tachycardia, but no severe adverse events were reported. Researchers say longer, larger trials are needed to assess long-term safety and benefit.

via Yahoo News Canada|

#cardiac-regeneration #clinical-trial #heart-failure

health3 days ago•47 min saved

Stem-cell therapy shows promising heart recovery in a small Chinese trial

In a small 12‑month trial at Nanjing Drum Tower Hospital, 10 heart‑failure patients received stem cells derived from their own iPSCs and differentiated into heart muscle cells injected into diseased heart tissue, while 10 controls underwent bypass surgery. Nine treated patients showed significant heart‑function improvements at 12 months versus the control group, with better six‑minute walk test results and an increased ejection fraction on average. No severe adverse events were reported in the treated group, though two patients experienced tachycardia that resolved. One control patient died eight months after surgery. While promising, the study’s tiny size means larger trials are needed to confirm safety and benefit.

via Yahoo|

#cardiac-function #clinical-trial #health

science4 days ago•40 min saved

KRAS-Targeted Drug Sparks Immune Defense to Prevent Pancreatic Cancer in High-Risk People

Johns Hopkins researchers report that an experimental KRAS-targeting drug was safe in a phase 1 trial of 20 people at high risk for pancreatic cancer and successfully activated KRAS-specific T-cells in 90% of participants, with immune responses persisting for about two years; while no cancers or high-risk lesions progressed during follow-up, the small study was not designed to prove prevention.

via Good News Network|

#clinical-trial #immunotherapy #kras

healthcare6 days ago•2 min saved

Personalized mRNA melanoma vaccine with Keytruda shows Phase 3 promise

Merck and Moderna reported that a personalized neoantigen mRNA vaccine, intismeran, added to Merck's Keytruda in adjuvant melanoma slowed recurrence and metastasis in a Phase 3 trial, signaling a potential new class of cancer immunotherapies, though detailed data have yet to be released.

via STAT|

#cancer-vaccine #clinical-trial #healthcare

health8 days ago•0 min saved

Investigational pancreatic cancer pill may double survival, early data suggest

An investigational drug called daraxonrasib given to a pancreatic cancer patient at Massachusetts General Hospital is described as a potential breakthrough, with early results indicating that survival could be doubled. The report frames this as a historic advance after decades of research, though access to full details currently requires login or subscription to the Globe.

via The Boston Globe|

#cancer-treatment #clinical-trial #daraxonrasib

health8 days ago•11 min saved

A Family's $4 Million Bet on a Groundbreaking Gene Therapy

Jo Kaur describes how her family created a patient‑driven initiative to develop a first‑in‑human gene therapy for their son with Cockayne syndrome, raising about $4 million to bring the treatment from concept to clinic and weighing whether to proceed with the procedure; three months post‑treatment, their son is clinically stable and showing encouraging signs, though long‑term benefits are still uncertain and the family aims to secure FDA approval to treat other children.

via aol.com|

#clinical-trial #cockayne-syndrome #fda

health9 days ago•4 min saved

Gut microbiome therapy shows early promise for peanut allergy

A small phase 1 trial suggests oral fecal microbiota transplantation from healthy donors may increase peanut tolerance in some adults with peanut allergy (6 of 15 participants across two stages). Safety was acceptable, and mouse studies supported a gut-bacteria–driven mechanism involving RORγt+ regulatory T cells and bile acid metabolites. While encouraging, results are preliminary and not ready for clinical use; researchers aim to develop purified microbiome therapies (MTT) and conduct larger trials over the coming years. In the meantime, standard care—strict avoidance and an emergency allergy plan—remains essential.

via Healthline|

#clinical-trial #fecal-microbiota-transplantation #gut-microbiome

health12 days ago•7 min saved

Gut microbiome transplant offers early hope for peanut allergy treatment

In a phase 1, open-label trial at Boston Children’s Hospital, 15 adults with peanut allergies received fecal microbiota transplants to reset the gut microbiome. Ten participants received FMT capsules and five later got a transplant after antibiotics; about 40% achieved meaningful, durable increases in peanut tolerance (up to 300–600 mg, with one participant tolerating 1,043 mg) lasting at least four months. Side effects were minor and no major adverse events occurred. While promising, larger randomized trials are needed and FMT is not yet ready for clinical use; mouse studies suggested two Bacteroides species may drive the protective effect.

via ScienceAlert|

#clinical-trial #fecal-microbiota-transplant #gut-microbiome

health13 days ago•6 min saved

Ten-Second Treatment Shows Promise to Stop Cavities in Young Children

An 830-child US trial finds silver diamine fluoride can halt decay in children aged 1–6 with a 10-second application, arresting decay in 54% of treated baby teeth at six months (vs 22.5% with placebo); while not yet FDA-approved for kids, SDF could broaden access to care, including in medical settings, though it permanently stains treated teeth and more safety data are needed for permanent teeth.

via ScienceAlert|

#clinical-trial #fda-approval #health

health13 days ago•8 min saved

Month-Long Vegan Diet Shifts DNA Methylation and Aging Clocks

In a small 4-week, isocaloric study of 48 healthy adults, those on a vegan diet showed a statistically significant ~1.7-year reduction on the PhenoAge biological aging clock, while a GrimAge clock showed a smaller, non-significant shift and a chronological-age clock trended higher. Immune-cell changes (lower neutrophils, higher CD4+ T cells) aligned with blood tests. Genome-wide DNA methylation shifts occurred but most did not survive correction for multiple comparisons, making results preliminary. Limitations include the small sample size and use of a less-clean vegan diet (allowing processed foods); researchers plan longer, more controlled studies to confirm findings.

via StudyFinds|

#aging #clinical-trial #dna-methylation

health15 days ago•7 min saved

Illinois patients begin expanded-access rollout of experimental pancreatic cancer drug

Illinois and other states are starting to treat metastatic pancreatic cancer patients with the experimental drug daraxonrasib under an FDA-expanded access program ahead of full FDA approval; early clinical data show a median survival of about 13 months with daraxonrasib versus about six months with additional chemotherapy, with doctors calling it a potential game changer. The drug is provided at no cost through Revolution Medicines, and physicians submit requests for each patient as several Illinois hospitals begin offering it.

via chicagotribune.com|

#city-of-hope-chicago #clinical-trial #daraxonrasib

mental-health16 days ago•24 min saved

Herbal boost: Basil extract eases depression and anxiety when added to antidepressants

In a randomized, single-blind trial, 60 adults with major depressive disorder and concurrent anxiety received sertraline plus either 1100 mg of dried basil leaf extract nightly or a placebo for four weeks. The basil group showed greater symptom reductions on both the Beck Depression Inventory and the Hamilton Anxiety Rating Scale, with depression dropping from about 39 to 21 and anxiety from about 33 to 13, compared with placebo reductions to roughly 30 and 25, respectively. Basil was well tolerated, but the study’s short duration and single-blind design mean longer-term effects and causality require further research; basil should be viewed as an add-on, not a replacement for standard care.

via PsyPost|

#anxiety #basil #clinical-trial

science18 days ago•12 min saved

Publicly funded trial finds psilocybin eases treatment-resistant depression

A publicly funded randomized trial found that a 25mg dose of psilocybin plus psychological support significantly boosted response (43% at 3 weeks, 56% at 6 weeks) and remission (40% at 3 weeks vs 3% placebo), with effects sustained through six weeks, suggesting psilocybin therapy could help treatment-resistant depression and warrants larger, publicly funded trials in community settings.

via The Independent|

#clinical-trial #depression #psilocybin

science19 days ago•5 min saved

Gut bacteria transplant shows promise in treating peanut allergy in humans

In a small human trial, six of 15 peanut-allergic participants could tolerate more peanut after receiving a fecal transplant from healthy donors, with four months of follow-up showing up to 600 mg of peanut protein tolerated in most responders, suggesting that reshaping the gut microbiome could offer lasting allergy relief—though responses varied and more research is needed.

via Nature|

#clinical-trial #fecal-transplant #gut-microbiome

science20 days ago•11 min saved

Psychedelic Help for Anorexia? Early Trial Hints at Recovery Boost

A small pilot study of 21 women with long-standing anorexia nervosa found that adding psilocybin (three doses) to intensive talk therapy reduced eating-disorder symptoms and increased motivation to recover for up to a year, though body-mass index did not change and there was no control group; some participants experienced profound shifts while others faced adverse experiences. Researchers caution that results are early and require larger, controlled trials to determine who may benefit and how best to implement this approach.

via Scientific American|

#anorexia #clinical-trial #eating-disorders