Tag

Clinical Trial

All articles tagged with #clinical trial

health2 days ago•38 min saved

First DIPG Cure Brings Hope for Pediatric Brain Cancer

A 13-year-old Belgian boy with DIPG became the first person in history to be cured of the fatal brain cancer after participating in the BIOMEDE trial, where everolimus eliminated his tumor with no recurrence to date; doctors suspect a rare genetic mutation made his tumor unusually responsive and plan to study organoids to replicate the results, while continuing exploration of therapies like immunotherapy—though this is not a universal cure and more research is needed.

via Yahoo|

#biomede #clinical-trial #dipg

science11 days ago•3 min saved

Tiny Edge Against Aging Markers Found in Daily Multivitamins, Study Says

In a 2-year randomized trial of 958 older adults (average age ~70), daily multivitamin–multimineral supplements modestly slowed increases in two DNA-based aging clocks (PCPhenoAge by ~2.6 months, PCGrimAge by ~1.4 months); cocoa extract had no effect. The benefit was larger for those with faster baseline aging. Limitations include a largely homogeneous sample and the small magnitude of effect; epigenetic clocks are preliminary biomarkers, so more diverse, longer studies are needed to determine if these changes affect health or lifespan.

via SciTechDaily|

#aging #clinical-trial #epigenetic-clocks

science11 days ago•7 min saved

Niacin Boosts Immune Response in Glioblastoma Trial

University of Calgary researchers are testing high-dose vitamin B3 (niacin) in addition to standard glioblastoma treatment. Early Phase I/II results in 24 patients show 82% progression-free at six months, a 28% improvement over historical data, suggesting niacin may restore immune function to attack tumors. Safety monitoring remains essential, and enrollment will expand to 48 participants by 2026–2027 to confirm benefits.

via SciTechDaily|

#brain-cancer #clinical-trial #glioblastoma

health13 days ago•12 min saved

Race Against Time to Fund Life-Saving Sanfilippo Treatment for a Toddler

Two-year-old Leni Forrester’s Sanfilippo syndrome progression could be halted by a US clinical trial, but UK funding is lacking. Her parents are urging government support and newborn screening expansion while raising funds (the trial costs about £5.5m) to access the treatment before irreversible brain damage and loss of mobility or speech occur.

via The Independent|

#clinical-trial #dementia #funding

health14 days ago•6 min saved

Brain’s Natural Repair Sets the Pace for Early Stroke Recovery

A University of Auckland–led ESPRESSO trial with 64 stroke survivors found that adding 90 minutes of high‑intensity hand/arm therapy daily for 15 days, starting within two weeks of stroke, did not improve three‑month outcomes versus standard care, whether delivered via immersive video-game therapy or conventional methods. The results suggest early recovery is driven by the brain’s natural repair processes and that pushing more therapy in the acute phase may not enhance recovery, though digital therapy was engaging and as effective as traditional therapy. Implications point to exploring biological treatments early and reserving intensive physical therapy for a later stage when patients can engage more fully.

via Neuroscience News|

#clinical-trial #digital-therapy #health

health17 days ago•4 min saved

Lyme Vaccine Delivers Promising 70%+ Protection in Major Trial, Heads to FDA Review

Pfizer and Valneva’s VALOR Phase III trial for PF-07307405 shows about 73% efficacy at preventing confirmed Lyme disease, but the primary endpoint's 95% confidence interval is wide (15.8%–93.5%), likely due to milder Lyme activity during the study; a separate analysis confirms the lower bound above 20%, supporting FDA-approval steps. The vaccine targets the OspA protein to block Borrelia burgdorferi in ticks, and if approved could significantly boost Lyme prevention for high-risk groups.

via Gizmodo|

#clinical-trial #health #lyme-disease

health17 days ago•5 min saved

No magic cancer test: a single blood test can't save lives

An Australian oncologist explains there is no universal 'everything' cancer test. The Grail Galleri blood test aims to detect cancer signals in the blood but failed to reduce late-stage cancer diagnoses in a large NHS trial, illustrating the gap between finding more cancers and saving lives. While early detection remains a key goal, simply detecting cancers earlier doesn’t guarantee better outcomes, so practical public health guidance focuses on prevention and careful interpretation of test results.

via The Guardian|

#blood-test #cancer #clinical-trial

health18 days ago•40 min saved

From Embarrassment to Clear Skin: A Psoriasis Sufferer’s Turnaround

A 47-year-old woman with plaque psoriasis endures years of failed treatments and emotional distress until she joins a clinical trial for ICOTYDE, the first oral therapy approved for the condition. Her symptoms dramatically clear, transforming both her skin and self-confidence, and she urges others not to let disease define them.

via Yahoo|

#clinical-trial #fda-approval #health

health18 days ago•2 min saved

Lyme vaccine shows strong efficacy in late-stage results but misses primary endpoint

Pfizer and Valneva's Lyme disease vaccine posted 73.2% efficacy starting 28 days after the fourth dose in a late-stage trial, but the study missed its primary endpoint under the worst-case scenario (15.8% efficacy in the initial analysis); a second analysis showed 74.8% efficacy, leading to plans for regulatory submissions, with no Lyme vaccine currently approved.

via NBC News|

#clinical-trial #health #lyme-disease

health19 days ago•39 min saved

From Shame to Clear Skin: A Psoriasis Patient’s Breakthrough Trial

A 47-year-old woman, Amber Dean, suffered years of physical and emotional torment from plaque psoriasis, enduring misdiagnoses and failed treatments until she joined a clinical trial for ICOTYDE, the first oral medication for the condition. She now reports full skin clearance and a renewed sense of self, calling the decision one of her best health choices and urging others not to be defined by the disease.

via Yahoo News Canada|

#amber-dean #clinical-trial #health

science20 days ago•6 min saved

Masked immunotherapy VIR-5500 shows early promise against prostate cancer

A masked T-cell engager called VIR-5500 demonstrated early promise in an ongoing advanced prostate cancer trial, with 82% of high-dose patients seeing PSA reductions and about half showing tumor shrinkage; masking aims to reduce inflammatory toxicity and enable safer, slower activation, though results are preliminary and not yet peer-reviewed.

via ScienceAlert|

#clinical-trial #immunotherapy #prostate-cancer

health24 days ago•6 min saved

Immunotherapy Shrinks Colon Cancer Tumors, Giving Family Hope

After a grim prognosis of two to three years, Spencer Laird’s stage IV colon cancer dramatically improved on a Duke Cancer Center immunotherapy trial with botensilimab and balstilimab: about a year in, nearly all 13 tumors disappeared and the largest remaining lesion shrank to 0.6 cm, while his CEA marker fell, offering the family more time with their daughter and renewed hope. The study targets microsatellite-stable colorectal cancer and aims for long-lasting control with fewer side effects, and researchers plan to expand enrollment and biomarker work. The Lairds began with a second opinion and now travel for ongoing Duke visits.

via WRAL|

#clinical-trial #colon-cancer #duke-cancer-center

health28 days ago•6 min saved

First-line immunotherapy yields dramatic shrinkage in metastatic colon cancer

A 30-year-old father with metastatic, microsatellite-stable colorectal cancer and 13 lung tumors enrolled in a Duke trial testing immunotherapy as a first-line treatment instead of chemotherapy. The therapy dramatically reduced tumors (from 13 to 3; the largest under 0.6 mm), offering a path toward remission and prompting hopes for broader use. Full trial results are due in April, but experts caution it’s not yet standard of care and research will continue to refine patient selection. The case highlights a potential shift in treating certain colorectal cancers when detected early in the disease course.

via CBS News|

#clinical-trial #colorectal-cancer #health

health1 month ago•5 min saved

Epilepsy drug sulthiame trims sleep apnea events by up to 50% in trial

A European phase II trial with 240 adults showed that nightly 200–300 mg sulthiame reduced sleep-apnea severity by about 30–50% versus placebo, improving breathing interruptions and oxygenation with no major safety concerns. The results suggest a direct pharmacological approach to sleep-disordered breathing, though longer and broader studies are needed to confirm durability and safety beyond CPAP-centered care.

via ScienceAlert|

#clinical-trial #health #pharmacotherapy

health-and-medicine1 month ago•6 min saved

New Pill May Tame Sleep Apnea, Cutting Breathing Pauses

A European double-blind trial with 298 participants found the drug sulthiame reduced breathing interruptions by up to 47% and improved overnight oxygen levels in adults with moderate to severe sleep apnea, suggesting a pill-based alternative to CPAP, though longer studies are needed to assess long-term safety and sustained effects.

via ScienceDaily|

#clinical-trial #cpap-alternative #health-and-medicine