Tag

Clinical Trial

All articles tagged with #clinical trial

health10 hours ago•6 min saved

Cheap meds offer brief fatigue relief in long-COVID, study finds

In a randomized trial of nearly 800 adults with long COVID in England, colchicine, a combo of famotidine and loratadine (antihistamines), and rivaroxaban were added to usual care for 12 weeks. Fatigue improved across all groups, with small extra reductions for colchicine and the antihistamine combo versus usual care; rivaroxaban had no significant effect. By 24 weeks, these benefits faded and there were no long-term differences, suggesting these drugs are not a cure and highlighting the need for further research into long-COVID immune dysfunction.

via CIDRAP|

#antihistamines #clinical-trial #colchicine

health6 days ago•7 min saved

Time-Restricted Fasting May Ease Weight Loss Without Heavy Calorie Counting

An 18‑month University of Adelaide trial with over 200 adults with obesity found that time‑restricted intermittent fasting (30% of energy on three nonconsecutive days, 8 am–12 pm, plus a 20‑hour fast) produced roughly the same weight loss as continuous calorie restriction (about 7 kg in six months), while feeling less restrictive than counting calories. Standard care yielded about 2 kg. The fasting group also reported mood and wellbeing improvements, suggesting IF may help people who struggle with traditional dieting, though long‑term effects require more research to identify who benefits most.

via SciTechDaily|

#clinical-trial #eating-behavior #health

health7 days ago•7 min saved

Implantable Vagus Nerve Stimulator Delivers Lasting Relief for Severe Depression in US Trial

The US RECOVER trial of 493 patients with severe, treatment-resistant depression found that an implanted vagus nerve stimulator produced lasting benefits: 69% had meaningful improvement at 12 months, and over 80% of those continued to improve or stay improved at 24 months; among strong early responders (50%+ symptom reduction), 92% remained improved at two years, and about one-third of initial non-responders improved by 24 months. While not a rapid fix and not universal in effect, the durable benefits (funded by device maker LivaNova) could influence coverage decisions for VNS as a treatment option.

via ScienceAlert|

#clinical-trial #depression #health

health8 days ago•7 min saved

WHO-backed Ebola therapy trial begins in DRC amid outbreak

The World Health Organization launches a trial of two therapeutics for the Bundibugyo strain of Ebola in the DRC, with the first patient enrolled as the outbreak in the DRC (and Uganda) continues. There have been about 1,406 confirmed DRC cases and 438 deaths as of June 30, with 20 Ugandan cases and one French case by July 1. There are no approved vaccines or treatments for this strain yet; the study is coordinated by DRC’s INRB, Belgium’s Institute of Tropical Medicine, and the University of Oxford, aiming to expand safe treatment options.

via BBC|

#bundibugyo-virus #clinical-trial #democratic-republic-of-the-congo

health-and-medicine12 days ago•7 min saved

Omega-3 Fish Oil Boosts Brain DHA But Fails to Improve Memory in Alzheimer's Risk Trial

A two-year, double-blind trial found that high-dose DHA from fish oil reached the brain but did not improve memory or cognitive function nor slow hippocampal shrinkage in older adults at risk for Alzheimer's, suggesting supplements may not protect brain health and highlighting the importance of overall diet and lifestyle.

via ScienceDaily|

#alzheimers-disease #brain-health #clinical-trial

science15 days ago•2 min saved

First Human Trial Tests Rejuvenation of Aging Eye Cells for Glaucoma

Scientists have begun the first human trial of partial cellular reprogramming to nudge aging eye cells toward a younger state in hopes of regenerating optic nerve neurons to treat glaucoma. The study by Life Biosciences treated the first participant and plans to enroll up to 12 total; this is an early, experimental approach—not a lifespans therapy—with cancer risk as a key concern and no results yet.

via geekspin|

#aging #cellular-reprogramming #clinical-trial

science16 days ago•45 min saved

First human trial tests partial reprogramming to reverse aging in glaucoma

Scientists have treated the first participant in an early-stage clinical trial testing partial cellular reprogramming to make aging cells act younger, aiming to regenerate optic nerve neurons in glaucoma. While promising, the approach is experimental, enrolling up to 12 participants, with potential cancer risk, and is not a universal anti-aging therapy.

via Yahoo|

#aging #cellular-reprogramming #clinical-trial

technology17 days ago•6 min saved

Tiny brain implant fights brain cancer with electrical therapy

Coherence Neuro, a San Francisco biotech tied to Neuralink, began testing a coin-sized brain implant by placing it temporarily in three patients undergoing brain-tumor surgery in Australia to sense tumor electrical activity and deliver mild stimulation aimed at slowing growth. The 30-minute implants, used as a safety check before longer-term use, could enable continuous monitoring and remote adjustment via an app, with plans for a permanent implant trial in glioblastoma patients next year, potentially offering a more convenient alternative to existing devices like Optune.

via WIRED|

#brain-cancer #brain-computer-interface #clinical-trial

health-and-medicine18 days ago•6 min saved

High-Dose Niacin Shows Promise Against Aggressive Brain Cancer

University of Calgary researchers are testing high-dose vitamin B3 (niacin) alongside standard glioblastoma treatment to revive immune cells and attack tumors. In an early Phase I/II trial, 24 patients showed a six-month progression-free survival of 82% — about 28% better than earlier studies — suggesting niacin could boost immune response against this deadly brain cancer, though safety at high doses remains a key consideration as the study continues toward 48 participants by late 2026/early 2027.

via ScienceDaily|

#clinical-trial #glioblastoma #health-and-medicine

health21 days ago•7 min saved

Fish oil supplements fail to slow Alzheimer’s decline in USC trial

A two-year, placebo-controlled study of 365 older adults at risk for Alzheimer’s found that high-dose DHA omega-3 supplements did not improve memory, cognition, or brain-structure measures, despite DHA reaching the brain; researchers suggest fish oil alone isn’t protective and that dietary patterns (e.g., Mediterranean diet) plus healthy lifestyle may be more effective for brain health.

via Keck Medicine of USC|

#alzheimers-disease #clinical-trial #dha

health23 days ago•373 min saved

First fentanyl vaccine shows early promise in humans

An experimental fentanyl vaccine developed by ARMR Sciences showed promising results in an early human trial, marking the first fentanyl vaccine tested in people and offering potential to prevent overdoses and aid addiction treatment if effectiveness is confirmed in larger studies.

via NBC News|

#clinical-trial #fentanyl #health

technology25 days ago•5 min saved

AI-designed universal coronavirus vaccine shows safety and immune response in first human trial

Researchers from Cambridge and Southampton used AI to design a ‘super-antigen’ vaccine intended to protect against multiple Sarbeco coronaviruses. In a Phase I trial, the vaccine was safe and elicited immune responses in 39 healthy volunteers when delivered via a needle-free micro-fluid jet, suggesting a potential future-proof solution against current and emerging coronaviruses, though larger and more diverse trials are needed and concerns about AI in medicine remain.

via Fox News|

#ai #clinical-trial #coronavirus

science27 days ago•3 min saved

AI-Designed DNA Vaccine Aims for Broad Coronavirus Protection

Cambridge researchers used a machine-learning model to design a DNA-based vaccine targeting the sarbecovirus family (SARS, COVID and related viruses), creating a “super-antigen” and conducting the first human trial of an AI-designed vaccine. In a 39-person study, the vaccine activated virus-fighting antibodies and was well tolerated across four doses, but the immune response was modest and durability is unknown. If successful, the approach could provide broad protection against current and future coronavirus mutations, with the benefits of stability and needle-free administration, though more research is needed.

via Futurism|

#artificial-intelligence #biotechnology #clinical-trial

health28 days ago•3 min saved

NHS CAR-T lupus trial yields remission in five patients

Nine patients with severe lupus in London took part in an NHS-led CAR-T cell therapy trial; five of the lower-dose recipients went into remission within months, with kidney function stabilization and notable quality-of-life gains (including skiing and dancing for one patient). Higher-dose patients are still being followed. If confirmed in larger studies, this immune‑reset approach could offer a potential cure and reduce lifelong medications.

via The Guardian|

#car-t #clinical-trial #health

science1 month ago•6 min saved

First patient treated in trial turning back cellular age to tackle glaucoma

The first participant has been treated in a landmark trial testing partial cellular reprogramming—activating three genes to make aged cells behave younger—in hopes of regenerating optic nerve neurons and treating glaucoma; safety is the primary focus, with low—but not zero—risk of cancer, and results will determine viability for broader use.

via Nature|

#aging #cellular-reprogramming #clinical-trial