Tag

Pediatric Sepsis

All articles tagged with #pediatric sepsis

Immune-escape SARS-CoV-2 BA.3.2 detected across US and 22 countries
public-health18 days ago

Immune-escape SARS-CoV-2 BA.3.2 detected across US and 22 countries

The CIDRAP digest reports the SARS-CoV-2 BA.3.2 variant—heavily mutated and potentially resistant to vaccines—has been detected in four US travelers, clinical samples from patients, and wastewater across 25 states, with detections in 23 countries and two sublineages (BA.3.2.1 and BA.3.2.2). National surveillance showed about 0.19% of recent sequences in the US (as of Feb 11, 2026), while 30% of sequences in parts of Europe were BA.3.2 in late 2025–early 2026, underscoring the need for ongoing genomic monitoring to assess public health impact. The issue also highlights that vaccination does not increase risk of sudden death in young people (a Canadian study showing 43% lower risk in vaccinated youths), a large pediatric sepsis study finding sepsis in 1.3% of hospitalized children and accounting for 18% of in-hospital pediatric deaths, and that expanded maternal syphilis screening raised case detection in the first quarter but waned within a year without additional measures. Quick takes note meningitis at a UK university, mpox in Missouri, and rising diphtheria risk across Africa."

"Phoenix Criteria: A New Tool for Pediatric Sepsis Diagnosis"
medical-research2 years ago

"Phoenix Criteria: A New Tool for Pediatric Sepsis Diagnosis"

A new study developed and validated the Phoenix Sepsis Score, a novel criteria for pediatric sepsis and septic shock based on organ dysfunction, using data from over 3.6 million pediatric encounters in 10 health systems. The Phoenix Sepsis Score outperformed existing organ dysfunction scores and the International Pediatric Sepsis Consensus Conference criteria, showing improved performance for diagnosing pediatric sepsis and septic shock across differently resourced settings. The study aims to provide improved criteria for identifying true-positive cases of pediatric sepsis while minimizing false-positive cases, with the goal of optimizing clinical care, research enrollment, and epidemiological surveillance.