Tag

Phase 2a

All articles tagged with #phase 2a

science2 hours ago•9 min saved

VH-499 HIV Pill Shows Early Promise in Phase 2a Human Trial

A Phase 2a study of VH-499 in 23 adults with HIV-1 showed dose-dependent viral load reductions by day 11 and good tolerability, with all treated participants experiencing declines unlike the placebo group. The drug may offer an alternative with fewer drug interactions compared with lenacapavir, but larger Phase 3 trials are needed to confirm safety and efficacy and to compare it directly with existing therapies.

via NDTV|

#capsid-inhibitor #clinical-trial #hiv

business3 months ago•2 min saved

Oruka's ORKA-001 Sparks Hopes for a Category-Winning Psoriasis Drug

Oruka Therapeutics reports phase 2a results for ORKA-001, a long-acting IL-23 inhibitor for plaque psoriasis, showing 63.5% of treated patients achieving complete skin clearance (40/63) at week 16 versus 1/21 on placebo, with a clean safety profile and potential for annual dosing. Jefferies analysts say the data could outperform Skyrizi and support $5–$10 billion in sales, helping the stock rise about 30% as the company moves to phase 3 with an active comparator.

via Fierce Biotech|

#business #il-23-inhibitor #orka-001