Parietal Cortex Regulates Memory Gene Activity.
Researchers have discovered that DNA methylation regulates the expression of PKMzeta, a gene implicated in long-term memory formation. Reduced levels of PKMzeta in the brain are associated with Alzheimer’s disease and other memory deficit disorders. The study showed that hypermethylation of a specific section of the PKMzeta gene resulted in significantly lower levels of the protein PKMzeta. The mechanism could pave the way for future medical innovations and drug development for memory-related disorders.