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Shp Nr0b2

All articles tagged with #shp nr0b2

health23 days ago•5 min saved

Breakthrough SHP protein could shield joints, slow osteoarthritis in early studies

South Korean researchers identify SHP (NR0B2) as a natural cartilage protector; in animal models, restoring SHP reduced joint damage and pain, and SHP gene delivery into damaged joints yielded lasting benefits, suggesting a potential approach to slow or prevent osteoarthritis—though human trials are needed and results are preclinical.

via Futura, le média qui explore le monde|

#cartilage #gene-therapy #health

science3 months ago•7 min saved

SHP Protein Emerges as Potential Breakthrough to Stall Osteoarthritis

Researchers have identified the SHP (NR0B2) protein as a key defender of cartilage whose levels fall as osteoarthritis progresses. Restoring SHP in animal models reduced cartilage damage, improved joint function, and dampened cartilage-degrading enzymes (MMP-3 and MMP-13) via the IKKβ/NF-κB pathway. Gene delivery of SHP into affected joints produced lasting benefits, suggesting a potential disease-modifying approach to slow or halt osteoarthritis.

via SciTechDaily|

#cartilage #gene-therapy #nf-kb-pathway