Tag

Cartilage

All articles tagged with #cartilage

health24 days ago•7 min saved

Guarding the Jaw: LOXL2 Enzyme Shows Promise Against TMJ Arthritis

Researchers identify LOXL2 as a protector of jaw cartilage in TMJ osteoarthritis. LOXL2 helps suppress the NF-κB inflammatory pathway, preserves chondrocyte viability, and maintains cartilage matrix. Loss of LOXL2 activates inflammatory genes and accelerates cartilage breakdown; boosting LOXL2 reduced inflammatory markers and protected cartilage in mouse and goat tissues, suggesting LOXL2 as a potential therapeutic target for TMJ disorders, though human studies and approved TMJ-specific treatments are still needed.

via SciTechDaily|

#cartilage #health #inflammation

science2 months ago•5 min saved

Enzyme Inhibition Reverses Cartilage Degeneration Without Stem Cells

Scientists have shown in mice that inhibiting the aging enzyme 15-PGDH can regrow cartilage without stem cells, with treated cartilage thickening into hyaline cartilage and reprogramming existing joint cells to build tissue. Early tests on human cartilage also show reduced enzyme activity and initial matrix rebuilding, suggesting a potential, less invasive path to treating osteoarthritis, though research is in early stages.

via Indian Defence Review|

#15-pgdh #aging #cartilage

science2 months ago•10 min saved

Blocking an Aging Enzyme Reawakens Cartilage Regeneration Without Stem Cells

Researchers inhibited the aging-associated enzyme 15-PGDH in mice, thickening previously thinned cartilage and shifting local cells toward healthier cartilage formation; early tests on human osteoarthritic cartilage showed reduced enzyme activity and initial signs of matrix rebuilding, suggesting a potential upstream therapy for cartilage loss that doesn’t rely on stem cells.

via ZME Science|

#15-pgdh #aging #cartilage

health2 years ago•2 min saved

"Promising Discoveries and Trials Offer Hope for Reversing Osteoarthritis"

Researchers at the University of Adelaide have discovered that osteoarthritis (OA) in mice is caused by the depletion of specialized gene-expressing cartilage-forming stem cells and have found a way to reverse the condition. The study suggests that OA may be treatable and reversible, challenging the notion that it is a "wear and tear" condition. By targeting fibroblast growth factor signaling, the researchers were able to stimulate the proliferation of these stem cells and achieve significant recovery of cartilage thickness and reduced OA. While the findings need to be tested in human subjects, a clinical trial using a similar approach has shown promise in improving cartilage thickness and volume.

via New Atlas|

#cartilage #health #osteoarthritis

health2 years ago•2 min saved

Revolutionary Treatment Approach Unveiled for Osteoarthritis and Neurodegenerative Diseases

Researchers have discovered that elevated levels of the protein c-Fos are associated with the severity of osteoarthritis, a common degenerative joint disease affecting over 500 million people worldwide. This breakthrough provides new insights into potential targeted therapies and challenges the previous belief that osteoarthritis solely stems from wear and tear. The study, led by scientists at MedUni Vienna, found that c-Fos is secreted by cartilage cells in response to osteoarthritis signals and plays a role in protecting cartilage. The research team also deciphered the mechanism controlling the production and accumulation of c-Fos in cartilage cells, paving the way for the development of targeted therapies.

via SciTechDaily|

#cartilage #health #joint-disease

health2 years ago•4 min saved

"Breakthrough Discovery: Protein Shields Joints from Osteoarthritis"

Researchers have identified a previously unstudied protein called adseverin that plays a critical role in protecting healthy joints from osteoarthritis. Adseverin helps maintain the structural scaffolding of cells, known as F-actin, which acts as a shield against the stresses on cartilage cells. Loss of F-actin leads to cell death and the degradation of cartilage. The findings may open doors to developing therapeutics targeting adseverin or F-actin to prevent joint degradation and improve osteoarthritis treatments.

via Medical Xpress|

#cartilage #health #joint-health

health3 years ago•3 min saved

Young cartilage eases arthritis pain.

Researchers are using cartilage from healthy joints that have been discarded due to polydactyly, a condition where a person is born with extra digits, to replace worn-out cartilage in patients with osteoarthritis of the knee. All ten patients treated with small sheets of cartilage made from unwanted fingers and toes as part of a pilot project at Tokai University in Tokyo, Japan, went on to show complete regeneration of their own cartilage in damaged knees over the following 12 months, avoiding the need for a replacement knee joint. This technique has the potential to allow people to walk their entire lives on their own knees, without requiring artificial joints.

via Daily Mail|

#arthritis #cartilage #health