Personalized mRNA melanoma vaccine with Keytruda shows Phase 3 promise
TL;DR
Merck and Moderna reported that a personalized neoantigen mRNA vaccine, intismeran, added to Merck's Keytruda in adjuvant melanoma slowed recurrence and metastasis in a Phase 3 trial, signaling a potential new class of cancer immunotherapies, though detailed data have yet to be released.
- Moderna and Merck say mRNA cancer vaccine succeeded in late-stage melanoma trial STAT
- Personalized cancer vaccine from Moderna, Merck shows promise in first late-stage melanoma trial CNBC
- Merck and Moderna Announce Phase 3 INTerpath-001 Trial of Intismeran Autogene Plus KEYTRUDA® Met Endpoints of Recurrence-Free Survival (RFS) and Distant Metastasis-Free Survival (DMFS) in Patients With Completely Resected Stage IIB-IV Melano Yahoo Finance
- Moderna-Merck MRNA Shot Helped Cut Melanoma Recurrence in Big Trial Bloomberg.com
- Cancer treatment could face landmark moment with promising vaccine The Washington Post
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