Creatine Boosts Muscle Mass and Memory in Sedentary Adults Aged 45–65

A 12-week study of 64 healthy, sedentary adults aged 45–65 found that creatine monohydrate (10 g/day) increased lean tissue mass, strength, and muscular endurance, and improved markers of cognitive function and memory. When combined with a supervised exercise and weight-loss diet, there was a greater reduction in body fat and additional gains in strength and cognition. Authors caution that cognitive/biomarker results are exploratory and that self-selection into the lifestyle program could have influenced outcomes.