Population-scale Insights into Somatic Mutations and Cancer Prevention
TL;DR
The article discusses the development of NanoSeq, an ultra-low error sequencing method, and its application to study somatic mutations and clonal landscapes in human tissues, particularly oral epithelium, revealing extensive mutation accumulation, positive and negative selection, and insights into carcinogenesis and risk factors across a large population cohort.
Topics:healthgenetics#cancer-risk#clonal-evolution#genetics#nanoseq#oral-epithelium#somatic-mutation
- Somatic mutation and selection at population scale Nature
- How smoking and alcohol shape mutations in our DNA Drug Target Review
- Cheek swabs to detect mutated genes ‘could become useful cancer prevention tool’ The Independent
- DNA sequencing tool reveals hidden mutations that drive cancer Pf Media
- Somatic Mutation and Selection Across Populations Bioengineer.org
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