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DNA-powered therapy halves 'bad' cholesterol, bypassing statins

1 min read
Source: ScienceDaily
DNA-powered therapy halves 'bad' cholesterol, bypassing statins
Photo: ScienceDaily
TL;DR

A DNA-based treatment using polypurine hairpins to silence PCSK9 lowers LDL cholesterol and boosts LDL receptors. In liver cells HpE9/HpE12 reduced PCSK9 RNA by up to 74% and protein by up to 87%; in transgenic mice a single injection cut PCSK9 by ~50% and cholesterol by ~47% within days, potentially offering a statin-free alternative with fewer side effects.

Topics:healthhealth-and-medicine#health-and-medicine#ldl-cholesterol#ldl-receptor#pcsk9#polypurine-hairpins#statins
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  1. New treatment cuts bad cholesterol by nearly 50% without statins  ScienceDaily
  2. If you have high cholesterol, there are alternatives to statins  MSN
  3. Rewriting the heart’s future  Borneo Bulletin

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