Tag

Pcsk9

All articles tagged with #pcsk9

health25 days ago•9 min saved

Oral PCSK9 Pill Cuts LDL Cholesterol by Up to 60% in Phase 3 Trial

A phase 3 trial of the daily oral PCSK9 inhibitor enlicitide showed LDL cholesterol falls by about 60% in 2,909 patients with atherosclerosis or high cardiovascular risk, many already on statins. The pill also reduced non-HDL cholesterol, apolipoprotein B, and lipoprotein(a), with effects lasting one year. If FDA approves, enlicitide could offer an oral alternative to injectable PCSK9 therapies and improve adherence, though a separate study is needed to confirm whether these LDL reductions translate into fewer heart attacks and strokes. The trial was Merck-funded and ongoing work aims to determine cardiovascular event outcomes.

via SciTechDaily|

#cholesterol #enlicitide #health

health5 months ago•2 min saved

Merck's PCSK9 Pill Shows Promise in Lowering Cholesterol to Injectable Levels

Merck has developed a new pill called enlicitide that significantly reduces LDL cholesterol levels by blocking the PCSK9 protein, showing promising results in clinical trials with a 20% reduction in heart attack and stroke rates among high-risk patients, and offering a potentially more affordable alternative to existing injectable treatments.

via The New York Times|

#cholesterol #enlicitide #health

health5 months ago•3 min saved

Revolutionary Gene Therapy Halves Cholesterol Without Statins or Side Effects

Researchers have developed a new therapy using polypurine hairpins to inhibit PCSK9, significantly reducing LDL cholesterol levels by nearly 50% without the side effects associated with statins, offering a promising alternative for managing hypercholesterolemia and preventing atherosclerosis.

via Science Daily|

#cardiovascular-health #cholesterol #health

health5 months ago•4 min saved

Innovative Epigenetic Techniques Achieve Long-Lasting Cholesterol Reduction

A new genetic therapy using polypurine hairpins to inhibit PCSK9 significantly reduces cholesterol levels by nearly 50%, offering a promising alternative to traditional statins and potentially reducing cardiovascular disease risk.

via SciTechDaily|

#cholesterol #genetic-therapy #groundbreaking-study

biotechnology3 years ago•4 min saved

The Far-Reaching Impact of Antibody Patent Disputes in Biotech

A patent case before the US Supreme Court over rights to therapeutic antibodies that are used to treat high cholesterol could have far-reaching impacts on drug prices and technology. The decision could affect how specific patents of any ilk must be when they describe an invention, and how broad they can be. A win by Amgen could hinder the development of new medicines by restricting competition and discouraging the development of multiple therapeutic antibodies that bind to the same target.

via Nature.com|

#antibodies #biotechnology #drug-prices