Tag

Statins

All articles tagged with #statins

health2 days ago•3 min saved

Early statin use linked to lower dementia risk in large Danish study

A 15-year Danish observational study of 132,585 individuals with type 2 diabetes found that starting statins was associated with a 15% lower dementia risk over 10 years when begun early (versus 10% if started later); while not proving causation, the findings—presented at the European Society of Cardiology congress and published in Lancet Regional Health Europe—support the idea that lowering LDL cholesterol and improving vascular health from midlife could help prevent or delay dementia.

via The Guardian|

#cardiovascular-health #dementia #health

health2 days ago•7 min saved

Statin therapy lowers major cardiovascular events by 30% in older adults without prior CV disease

In the STAREE trial, about 9,971 adults aged 70+ without cardiovascular disease or diabetes who were randomized to atorvastatin 40 mg daily had a 30% lower risk of major cardiovascular events over a median follow-up of 5.9 years versus placebo, driven largely by fewer nonfatal myocardial infarctions and fewer revascularizations. There was no significant improvement in disability-free survival (death, dementia, or persistent disability), LDL cholesterol fell substantially in the statin group, and adverse events were more common but serious events were rare. The findings support statin use for primary prevention in some healthy older adults but may not apply to frail or multimorbid individuals.

via Medscape|

#cardiovascular-events #elderly #health

health3 days ago•3 min saved

Healthy seniors over 70 may gain protection from daily statins, trial shows

A world-first randomized trial in nearly 10,000 Australians over 70 without prior heart disease found that daily statin use reduced the risk of a first major cardiovascular event by 30% over about six years, with one event prevented for every 37 people treated. The study, published in the New England Journal of Medicine and presented at the European Society of Cardiology Congress, suggests older adults should discuss statin therapy with their GP; side effects were low and dementia risk did not increase, but adherence was an issue and results may not generalize to all populations.

via The Guardian|

#australia #cardiovascular-disease #elderly

health4 days ago•8 min saved

Calcium score tests rarely change heart-risk decisions, study finds

A JAMA study of about 6,000 adults shows the PREVENT heart-disease risk calculator alone accurately predicts near-term events for most people; adding a coronary artery calcium (CAC) score provides little extra value except as a tiebreaker for those at borderline/intermediate risk, where a higher CAC score may influence statin decisions. For high- or low-risk individuals, CAC typically wouldn’t alter treatment, suggesting CAC scans should be reserved for select middle-risk patients and discussed with a clinician.

via The Washington Post|

#cac-scan #calcium-scoring #health

health14 days ago•62 min saved

Cardiologists Say CoQ10 Is Usually a Waste—Choose Diet, Exercise, Sleep Instead

Cardiologists warn that CoQ10 supplements offer uncertain value for heart health and can interfere with medications like warfarin and diabetes drugs, making them a questionable use of time and money. They urge evidence-based lifestyle changes—eat a heart-healthy diet (Mediterranean/DASH), aim for at least 150 minutes of aerobic activity plus resistance training each week, and prioritize sleep—as more reliable ways to protect the heart, noting CoQ10 may have niche use only under medical supervision or in very specific deficiencies.

via AOL.com|

#cardiology #coq10 #health

health18 days ago•3 min saved

Very High LDL Triggers Aggressive Statin Therapy, Roach Says

In a health Q&A, Dr. Roach explains that an LDL over 190 mg/dL carries high cardiovascular risk, so statin therapy is recommended—even for younger patients—though the dose is debated. A patient on rosuvastatin 40 mg plus ezetimibe is reasonable, but many clinicians tailor dosing to reach LDL goals (often <70 mg/dL) by starting lower and titrating. In a second question, diet sodas can erode tooth enamel and may influence gut microbiome and future glucose control; they don’t reliably raise A1C in the short term, but water is best, with sugar-sweetened beverages worse for health.

via The Detroit News|

#cholesterol #diet-soda #ezetimibe

health19 days ago•61 min saved

Guideline Shift Expands Statin Eligibility to 87.5 Million Americans

A JAMA analysis of the 2026 ACC/AHA cholesterol guidelines shows 21.5 million more U.S. adults now qualify for statins, bringing the total to about 87.5 million. The expansion focuses on long-term lifetime risk rather than just 10-year risk, with older adults and people with risk factors more likely to qualify. Whether to start a statin should be individualized, possibly aided by tests like coronary calcium scoring, alongside lifestyle changes; statins are generally safe with mostly minor side effects.

via AOL.com|

#cardiovascular-disease #cholesterol #guidelines

health20 days ago•6 min saved

Stopping Statins at 75: French Trial Suggests Possible Safety for Healthy Seniors

A French randomized trial in healthy adults around age 80 found that stopping statins at age 75 did not worsen three-year outcomes compared with continuing them; LDL rose after stopping, but death rates and major cardiovascular events were similar and quality of life remained unchanged. The findings may apply only to low-risk, healthy elderly populations and should not change practice broadly; decisions should be individualized and confirmed with longer follow-up and diverse populations.

via STAT|

#cardiovascular-disease #deprescribing #elderly

health25 days ago•3 min saved

Viagra's Secret: Sildenafil May Slow Cancer Spread by Blocking Cellular Cholesterol

A Weizmann Institute study (with U.S. data) suggests sildenafil (Viagra) can limit cancer’s ability to metastasize by disrupting cholesterol use inside cells via PDE5 inhibition and higher cGMP; researchers propose combining Viagra-related drugs with statins to slow spread. However, findings are observational and based on mouse data, so not yet proven in humans.

via LiveNOW from FOX|

#cancer-metastasis #cholesterol #health

science26 days ago•8 min saved

Viagra May Slow Cancer Spread by Trapping Cholesterol, Study Finds

Sildenafil (Viagra) appears to disrupt cholesterol trafficking in cancer cells, limiting their ability to spread in mouse models of breast, lung, and colon cancer, while a retrospective analysis of health records from over 40,000 male cancer patients linked combined sildenafil and statin use to about a 31% lower five-year mortality versus neither drug. The results are observational and require clinical trials to confirm causality.

via StudyFinds|

#cancer #cholesterol #metastasis

health26 days ago•79 min saved

Statins and Blood Pressure: Tiny Drops, Real Guidance

Statins are prescribed to lower cholesterol, not to lower blood pressure, but some research shows they can cause a small, gradual BP decrease in certain people over time due to improved endothelial function, reduced vessel inflammation, and plaque stabilization; the effect is typically modest. If you notice a drop in blood pressure after starting a statin, don’t stop the medication on your own—recheck readings after resting and discuss with your doctor, while considering other factors like dehydration or other meds. Keep a log of readings and symptoms and seek guidance if readings are repeatedly low or accompanied by dizziness or fainting.

via Woman's World|

#blood-pressure #cardiovascular-health #cholesterol

health27 days ago•8 min saved

Fructose as a Hidden Signal May Drive Ovarian Cancer Spread

Researchers at The Wistar Institute found that fructose released by treatment-surviving ovarian cancer cells acts as a signal that weakens cell–cell adhesion and promotes detachment and spread. The effect can occur even without chemotherapy, and higher dietary fructose may influence tumor behavior, with cholesterol-lowering statins also weakening cancer cell adhesion. The study, published in Nature Aging, raises the possibility that this mechanism could occur in other torso-spreading cancers, though clinical studies are needed.

via SciTechDaily|

#chemotherapy #fructose #health

cholesterol-and-cardiovascular28 days ago•29 min saved

Lipfendra: the first daily oral PCSK9 inhibitor and how it compares with statins

The FDA approved Lipfendra (enlicitide), the first oral PCSK9 inhibitor for high cholesterol and heterozygous familial hypercholesterolemia. In trials, Lipfendra lowered LDL cholesterol by about 56–59% versus placebo, mainly in patients already on statins, but there’s no head‑to‑head comparison with statins yet. It can be used alongside statins or other lipid drugs when LDL remains above goal, offering a pill alternative to injectable PCSK9 inhibitors. However, it’s approved only for adults, has a stringent morning-on-empty-stomach regimen, and more cardiovascular outcomes data are still being gathered, so doctors will tailor its use to patients who need additional LDL lowering beyond maximally tolerated statin therapy.

via Medical News Today|

#cholesterol #cholesterol-and-cardiovascular #ldl-cholesterol

cardiology28 days ago•3 min saved

Coronary Calcium Scoring Refines Heart-Risk Benchmarks and Statin Decisions

Adding coronary artery calcium (CAC) scoring to PREVENT-ASCVD risk estimates helped reclassify adults into more accurate risk categories and guide statin decisions in a US cohort; CAC=0 was linked to lower observed ASCVD risk and CAC>0 to higher risk, especially when statin eligibility was uncertain, with CAC-enhanced risk stratification improving net reclassification across risk tiers.

via Medscape|

#ascvd-risk #cardiac-ct #cardiology

health29 days ago•5 min saved

New Lipid Drugs and Updated Guidelines Expand Statin Eligibility, Redefining Cholesterol Care

Inclisiran lowers LDL by about 49% versus placebo in a meta-analysis and is a twice-yearly option that can be used with or without statins; Lipfendra (enlicitide), the first oral PCSK9 inhibitor, lowered LDL by roughly 56–59% in trials; combined with updated U.S. cholesterol guidelines that may make over half of adults eligible for statin therapy, these developments indicate a shift toward broader, personalized cholesterol management and adherence-friendly therapies.

via Healthline|

#cholesterol-guidelines #health #inclisiran