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Ldl Cholesterol

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ApoB Test Could Refine Heart-Risk Assessment Beyond LDL
health3 days ago

ApoB Test Could Refine Heart-Risk Assessment Beyond LDL

A recent JAMA study suggests that the apolipoprotein B (apoB) test, which counts harmful cholesterol particles, may identify people at risk for heart attack or stroke more accurately than standard LDL measurements; using apoB to guide when to intensify statin therapy could prevent more cardiovascular events, but it should be used as an additive tool alongside the regular lipid panel, especially for those with diabetes, obesity, metabolic syndrome, or high triglycerides.

via NDTV|
#apob#cardiovascular-risk#cholesterol-testing
Portfolio Diet May Cut LDL as Much as Statins by Mixing Four LDL-Lowering Foods
health26 days ago

Portfolio Diet May Cut LDL as Much as Statins by Mixing Four LDL-Lowering Foods

The portfolio diet combines four LDL-lowering components—plant protein (soy), plant sterols, tree nuts, and soluble fiber—into a daily plan and may reduce LDL cholesterol by up to about 29–30%, in some cases rivaling low-dose statins. Key targets include 35 g/day of plant protein, 2 g/day of plant sterols, 42 g/day of tree nuts, and 18 g/day of soluble fiber, with psyllium husk and fortified foods helping meet goals. While promising, statins have additional benefits beyond LDL reduction, and you should follow a clinician’s advice if prescribed.

via HuffPost UK|
#health#ldl-cholesterol#plant-sterols
Cholesterol Guidelines Push Proactive Screening, Personal Risk, and Sharper LDL Targets
health29 days ago

Cholesterol Guidelines Push Proactive Screening, Personal Risk, and Sharper LDL Targets

Updated ACC/AHA cholesterol guidelines emphasize earlier detection and personalized risk assessment, with more aggressive LDL-C lowering and a new PREVENT risk calculator for 10- and 30-year risk starting at age 30; recommend one-time Lp(a) testing, consider risk enhancers and coronary calcium scoring to tailor therapy, set LDL targets of <100 mg/dL for most, <70 mg/dL for intermediate risk, and <55 mg/dL for high risk, and expand therapies beyond statins (ezetimibe, bempedoic acid, PCSK9 inhibitors); childhood screening for familial hypercholesterolemia is advised, while lifestyle remains foundational.

via SciTechDaily|
#cholesterol-guidelines#coronary-calcium-screening#health
Cholesterol Guidelines Push Early Screening and Personalized Care
health1 month ago

Cholesterol Guidelines Push Early Screening and Personalized Care

The ACC/AHA issued major updates to cholesterol guidelines—the first since 2018—emphasizing earlier detection (including possible screening starting at age 9 for those with a family history), more aggressive, personalized statin therapy, and a renewed focus on lifestyle changes; saturated fats are highlighted as the primary dietary driver of blood cholesterol, not dietary cholesterol, and a new validated tool helps clinicians tailor treatment.

via 9and10News.com|
#cholesterol-guidelines#health#ldl-cholesterol
DNA-powered therapy halves 'bad' cholesterol, bypassing statins
health-and-medicine2 months ago

DNA-powered therapy halves 'bad' cholesterol, bypassing statins

A DNA-based treatment using polypurine hairpins to silence PCSK9 lowers LDL cholesterol and boosts LDL receptors. In liver cells HpE9/HpE12 reduced PCSK9 RNA by up to 74% and protein by up to 87%; in transgenic mice a single injection cut PCSK9 by ~50% and cholesterol by ~47% within days, potentially offering a statin-free alternative with fewer side effects.

via ScienceDaily|
#health-and-medicine#ldl-cholesterol#ldl-receptor
Cholesterol drug cuts first cardiovascular events by 31% in diabetics without artery disease
health-and-medicine3 months ago

Cholesterol drug cuts first cardiovascular events by 31% in diabetics without artery disease

A Mass General Brigham study finds the PCSK9 inhibitor evolocumab, added to standard therapy, reduces the risk of a first major cardiovascular event by 31% over ~5 years in high‑risk diabetics without diagnosed atherosclerosis, with about a 51% drop in LDL‑C. Safety was similar to placebo, suggesting earlier intensive cholesterol lowering may prevent heart attacks and strokes in patients without established artery disease; results were presented at the ACC and published in JAMA.

via ScienceDaily|
#cardiovascular-disease#diabetes#evolocumab
2026 Lipid Guidelines Use PREVENT Scores to Tailor Therapy
health3 months ago

2026 Lipid Guidelines Use PREVENT Scores to Tailor Therapy

The 2026 American dyslipidemia guideline endorses PREVENT-ASCVD risk equations to guide primary prevention therapy and suggests considering lipid-lowering treatment for adults at intermediate risk based on a 10-year PREVENT-ASCVD risk, with additional considerations for borderline risk and for patients with moderate subclinical atherosclerosis, aiming to lower LDL cholesterol.

via MedPage Today|
#dyslipidemia#guidelines#health
2026 ACC/AHA Dyslipidemia Guideline Emphasizes Early Intervention and PREVENT-ASCVD
health3 months ago

2026 ACC/AHA Dyslipidemia Guideline Emphasizes Early Intervention and PREVENT-ASCVD

The 2026 ACC/AHA Guideline on Dyslipidemia consolidates evidence-based recommendations, retires the 2018 cholesterol guideline, and stresses earlier lifestyle measures from childhood along with earlier pharmacotherapy for familial hypercholesterolemia and high LDL-C. It also adopts the PREVENT-ASCVD risk equations to guide lipid-lowering therapy in adults aged 30–79, aiming to improve ASCVD prevention.

via American College of Cardiology|
#accaha-guideline#dyslipidemia#familial-hypercholesterolemia
New ACC/AHA Dyslipidemia Guideline Promotes Early Lifestyle Action and Risk-Tailored Therapy
heart-news3 months ago

New ACC/AHA Dyslipidemia Guideline Promotes Early Lifestyle Action and Risk-Tailored Therapy

The ACC, AHA and partners released an updated dyslipidemia guideline that emphasizes earlier lifestyle changes, lower LDL-C targets based on individual risk, and earlier use of lipid-lowering therapies; it introduces the PREVENT-ASCVD risk calculator for primary prevention, expands testing for lipids including lipoprotein(a) and apolipoprotein B, and recommends selective use of coronary calcium scoring to guide treatment decisions, with guidance extending to pediatric screening and different populations to reduce lifetime ASCVD risk.

via www.heart.org|
#coronary-calcium-scoring#dyslipidemia#heart-news
Two Days of Oats Trim LDL Cholesterol by 10% and Rewire Gut Bacteria
health-and-medicine4 months ago

Two Days of Oats Trim LDL Cholesterol by 10% and Rewire Gut Bacteria

A two-day, calorie-restricted, oat-dominant diet reduced LDL cholesterol by 10% in people with metabolic syndrome, with modest weight loss and lower blood pressure, and benefits persisted six weeks. The effect appears linked to changes in gut bacteria and their metabolites; a longer, less intensive oat plan yielded smaller gains.

via ScienceDaily|
#gut-microbiome#health-and-medicine#ldl-cholesterol
Two-Day Oatmeal Diet Cuts LDL by 10%, Study Finds
health4 months ago

Two-Day Oatmeal Diet Cuts LDL by 10%, Study Finds

A German study from the University of Bonn found that consuming 300 grams of oats per day on a calorie‑restricted diet for two days lowered “bad” LDL cholesterol by about 10%, with slight weight loss and blood pressure reductions among adults with metabolic syndrome; the effect may stem from gut microbiome changes. While oats aren’t a replacement for medication, short, regular oat-based diets could help keep cholesterol in the normal range and may reduce diabetes risk, though diabetics should monitor carbs and ensure gluten-free oats if needed.

via AOL.com|
#health#ldl-cholesterol#metabolic-syndrome
Partial adherence to the Portfolio Diet lowers LDL cholesterol, new evidence shows
health5 months ago

Partial adherence to the Portfolio Diet lowers LDL cholesterol, new evidence shows

The Portfolio Diet—built around plant protein, nuts and seeds, viscous fiber, plant sterols and monounsaturated fat—significantly lowers LDL cholesterol, with about a 28% reduction when fully followed and a meaningful 14% drop with partial adherence; endorsed by major health organizations, it’s practical to start with small changes (e.g., plant-based proteins, oats, nuts, olive oil) for cardiovascular benefits.

via The Globe and Mail|
#health#heart-health#ldl-cholesterol
Understanding LDL Cholesterol and Ways to Reduce It
health6 months ago

Understanding LDL Cholesterol and Ways to Reduce It

LDL cholesterol, often called 'bad' cholesterol, can build up silently in arteries, increasing the risk of heart disease and stroke. It is essential to have regular blood tests to monitor levels, ideally keeping LDL below 100 mg/dL, and to understand that genetics and aging also influence cholesterol levels. Managing diet, lifestyle, and regular check-ups are key to controlling LDL cholesterol and maintaining heart health.

via GQ|
#blood-test#cardiologists#health