Unveiling Age-Related Changes in Immune Function Through Multi-Omic and Single-Cell Analyses
TL;DR
This study uses multi-omic profiling over two years to reveal that in healthy adults, immune system changes with age are characterized by stable, transcriptional reprogramming of T cells, a progressive TH2 bias in memory T cells, and altered B cell responses to influenza vaccination, with minimal influence from chronic CMV infection or systemic inflammation prior to advanced age.
Topics:healthhealth-and-science#b-cells#health-and-science#immune-aging#longitudinal-study#t-cells#vaccination-response
- Multi-omic profiling reveals age-related immune dynamics in healthy adults Nature
- Aging Reprograms T Cell Behavior, Weakening Vaccine Responses the-scientist.com
- HGTV Meets Biology: Inside our Mid-Life Immune Renovation American Council on Science and Health
- Multi-omic Insights into Aging Immune Dynamics Bioengineer.org
- Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging Nature
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