Exercise Boosts Fat Loss and Muscle Preservation With Semaglutide, Study Suggests

A mouse study presented at the European Atherosclerosis Society Congress 2026 shows that combining semaglutide (Ozempic) with regular exercise yields greater fat loss and far less lean-mass loss than semaglutide alone, while also improving insulin sensitivity, lipid levels, liver fat, and atherosclerotic changes. The exercise+drug group also showed improved grip strength and muscle fibre size, suggesting exercise may enhance the drug's effects and protect muscle during weight loss. Human trials are needed to confirm these results.