Tag

Lean Mass

All articles tagged with #lean mass

health1 month ago•2 min saved

Muscle-sparing antibody may lessen lean tissue loss with tirzepatide weight-loss therapy

A small Nature Medicine trial found that adding the monoclonal antibody apitegromab to tirzepatide (a GLP-1–based obesity drug) did not change total weight loss but reduced lean mass loss to about 1.6 kg (3.5 lb), or 14.6% of total weight loss, versus 3.5 kg with tirzepatide plus placebo—a 55% greater retention of lean tissue. Most participants were women; the study was limited in size and duration, so larger, longer trials are needed to assess safety and real-world benefits. Researchers also emphasize maintaining physical activity to help preserve muscle mass during weight-loss therapy.

via The Guardian|

#apitegromab #glp-1-weight-loss-drugs #health

health1 month ago•3 min saved

Exercise Boosts Fat Loss and Muscle Preservation With Semaglutide, Study Suggests

A mouse study presented at the European Atherosclerosis Society Congress 2026 shows that combining semaglutide (Ozempic) with regular exercise yields greater fat loss and far less lean-mass loss than semaglutide alone, while also improving insulin sensitivity, lipid levels, liver fat, and atherosclerotic changes. The exercise+drug group also showed improved grip strength and muscle fibre size, suggesting exercise may enhance the drug's effects and protect muscle during weight loss. Human trials are needed to confirm these results.

via NDTV|

#exercise #health #lean-mass

health2 months ago•6 min saved

GLP-1 Weight Loss Primarily Shrinks Fat, Not Muscle, Study Finds

A new study combining mouse experiments and a small human trial finds GLP-1 obesity drugs primarily reduce fat with only modest lean-mass loss, much of which reflects non-muscle tissue such as liver fat. Muscle strength and function are largely preserved, especially with regular exercise, and DXA measurements can misclassify lean tissue. The takeaway is that fat loss drives the benefit and functional outcomes matter more than absolute muscle size.

via American Council on Science and Health|

#glp-1 #health #lean-mass

health3 years ago•6 min saved

The downside of weight loss drugs: muscle loss.

Weight loss drugs can lead to loss of lean mass, including muscle, which can decrease resting metabolic rate and affect overall health. However, studies have shown that at the end of the weight loss period, people may have a healthier body composition with a higher ratio of lean mass to fat. To mitigate lean mass loss, it is important to eat enough protein and engage in resistance training. People on weight loss drugs should stay in close contact with their healthcare team to monitor muscle loss, kidney function, and electrolyte levels. There are currently no guidelines for physicians counseling patients on weight loss drugs.

via Yahoo News|

#health #lean-mass #metabolism

health3 years ago•6 min saved

The Impact of Weight Loss and Gain Medications on Your Body.

Weight loss drugs can lead to the loss of lean mass, including muscle, which can decrease resting metabolic rate and affect overall health. However, at the end of the weight loss period, people may have a healthier body composition with a higher ratio of lean mass to fat. To mitigate lean mass loss, people should eat enough protein and engage in resistance training. Physicians need research-backed recommendations for counseling patients on weight loss drugs, especially for older people.

via NBC News|

#health #lean-mass #metabolism