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Autoimmune Mechanisms in ALS Reveal New Disease Insights

1 min read
Source: Nature
Autoimmune Mechanisms in ALS Reveal New Disease Insights
Photo: Nature
TL;DR

The study identifies C9orf72 as a major autoantigen targeted by CD4+ T cells in ALS patients, with responses skewed towards an anti-inflammatory profile, especially in those with longer survival, suggesting a potential protective immune component in ALS progression.

Topics:healthmedical-research#als#autoimmune-response#c9orf72#medical-research#neurodegeneration#t-cells
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  1. Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis  Nature
  2. ALS Breakthrough Shows Fatal Disease Is Driven by Immune Attack  Bloomberg.com
  3. ALS appears to be an autoimmune disease  La Jolla Institute for Immunology
  4. Immune checkpoints may predict ALS severity, progression  ALS News Today
  5. Autoimmune responses found in ALS, pointing to a new way to view the deadly disease  statnews.com

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