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Als

All articles tagged with #als

Targeting TDP-43's Conserved Region Shields Neurons in ALS Models
science5 days ago

Targeting TDP-43's Conserved Region Shields Neurons in ALS Models

Scientists identify a conserved region (CR; residues 320–340) in TDP-43's low-complexity domain as a drug target. Deleting CR or treating with XL20, a brain-penetrant molecule that binds CR, dampens TDP-43 toxicity, corrects mitochondria-related dysfunction via LLPS, and prolongs survival in ALS mouse models, with positive effects in human mutant TDP-43 motor neurons, all while preserving TDP-43 splicing. XL20 shows CNS penetration and good safety, supporting CR targeting as a therapeutic strategy for TDP-43–related neurodegeneration.

via Nature|
#als#llps#neurodegeneration
Challenging the Shield: Journalists Demand Tougher NFL Health Questions on ALS
sports7 days ago

Challenging the Shield: Journalists Demand Tougher NFL Health Questions on ALS

Jeff Pearlman and Dan Le Batard push back on media passivity regarding the NFL-ALS link after Chris Johnson revealed his ALS diagnosis on Good Morning America. They argue that the press should question the league about health impacts, noting studies linking football to higher ALS risk and criticizing reporters like Michael Strahan for avoiding football-related questions. The discussion frames journalism ethics in sports as a resistance to a sport industry eager to keep fans comfortable, highlighting how tough questions about the game’s tolls can and should be asked rather than avoided.

via Awful Announcing|
#als#dan-le-batard#jeff-pearlman
ALS rallying cry: Chris Johnson’s diagnosis fuels Tim Shaw’s fight
sports10 days ago

ALS rallying cry: Chris Johnson’s diagnosis fuels Tim Shaw’s fight

Former NFL running back Chris Johnson revealed he has ALS, a disclosure that has given Tim Shaw renewed hope in his own battle with the disease. Shaw credits Johnson’s positive attitude and pursuit of treatments—recent therapies and ongoing clinical trials—for lifting him out of survival mode and motivating him to push forward alongside other NFL veterans advocating for ALS research.

via NBC Sports|
#als#chris-johnson#clinical-trials
ALS and football: recognizing the link that should not be ignored
sports11 days ago

ALS and football: recognizing the link that should not be ignored

Former NFL running back Chris Johnson publicly revealed his ALS diagnosis; the piece argues that a proven link between football and ALS exists, citing studies showing NFL players have about four times higher ALS risk and noting that the link should be acknowledged in discussions of the sport’s risks for players and parents, while also acknowledging that head injuries risk spans many sports.

via NBC Sports|
#als#brain-injury#chris-johnson
Chris Johnson Reveals ALS Diagnosis, Plans to Fight and Inspire
teamfootball-news12 days ago

Chris Johnson Reveals ALS Diagnosis, Plans to Fight and Inspire

Former Titans running back Chris Johnson announced he has ALS, sharing the news in a Good Morning America interview. Diagnosed last year, the disease has progressed rapidly and Johnson now uses a speech-generating device controlled by his eyes. He says if his story can spur earlier diagnosis, more research, or hope for families, it will be worth it, and he’s committed to fighting the disease while continuing his involvement with the Titans and his family.

via Tennessee Titans|
#als#chris-johnson#good-morning-america
Former Titans RB Chris Johnson reveals ALS diagnosis on GMA
sports12 days ago

Former Titans RB Chris Johnson reveals ALS diagnosis on GMA

Former Titans running back Chris Johnson sat for a Monday interview with Michael Strahan on Good Morning America and publicly disclosed his ALS diagnosis, a development teased by promos and highlighted by his CJ2K 2009 season (2,006 rushing yards). The piece notes ABC’s press release confirming the sit-down, a Titans YouTube highlight reel tied to the interview, and fan speculation about what Johnson would share.

via A to Z Sports|
#als#chris-johnson#cj2k
Brain-computer implant unlocks fluent speech for ALS patient at home
technology21 days ago

Brain-computer implant unlocks fluent speech for ALS patient at home

A brain-computer interface implanted in the speech motor cortex allowed an ALS patient who had been unable to speak for years to produce fluent, real-time speech at home. The system decodes neural signals into words with about 99% accuracy over a 125,000-word vocabulary at roughly 56 words per minute, and has been used for thousands of hours over a year with a privacy mode to control data recording. This shift from lab demonstrations to independent home use marks a major step toward practical speech restoration, though the technology remains invasive and experimental, not yet widely available, as the broader BCI field (including Neuralink and others) continues to tackle scalability, regulation, and access questions.

via Space Daily|
#als#brain-computer-interface#home-use
Brain-Computer Implant Restores a Personal Voice for a Paralyzed Man
science22 days ago

Brain-Computer Implant Restores a Personal Voice for a Paralyzed Man

A man with advanced ALS and near-total paralysis can communicate again using an implanted brain–computer interface that translates neural activity into text and a digital voice. In the BrainGate 2 trial, Casey Harrell has used the system at home for about two years, producing more than 183,000 sentences and nearly 2 million words at roughly 56 words per minute with ~92% accuracy, enabling independent emailing, web use, and work. Developed by UC Davis with Brown University and Mass General Brigham, the device includes privacy mode to mute thoughts, and researchers hope to refine it for broader use among 27 participants in total.

via ScienceAlert|
#als#brain-computer-interface#braingate
AI-powered brain-computer interface lets paralyzed ALS patient speak and work full-time
technology24 days ago

AI-powered brain-computer interface lets paralyzed ALS patient speak and work full-time

A UC Davis BrainGate study implanted a brain–computer interface in an ALS patient to decode brain signals into spoken language using BRAND, a machine-learning system. The patient, Casey Harrell, can control a computer and speak, enabling him to work full-time. In lab tests the system achieved 99% sentence accuracy; in daily life it’s 92%, with over 3,800 hours of use since 2023. The setup relies on existing hardware and home-care hookup, signaling a path toward practical, at-home BCI communication beyond the lab and toward broader commercialization.

via The Register|
#als#brain-computer-interface#braingate
Home Brain Implant Restores Speech and Computer Use for ALS Patient
technology25 days ago

Home Brain Implant Restores Speech and Computer Use for ALS Patient

A 48-year-old man with amyotrophic lateral sclerosis uses an implanted brain-computer interface at home to translate neural activity into text, enabling him to communicate at about 56 words per minute and to operate his computer and stay employed; over ~23 months he produced 183,060 sentences with 92% decoded at least mostly correctly, with a privacy mode, demonstrating day-to-day viability of BCIs as medical devices.

via Nature|
#als#at-home-use#brain-computer-interface