VEXAS Syndrome: UBA1 Mutations Drive Inflammation and Myeloid Bias
TL;DR
The study investigates how UBA1 mutations in VEXAS syndrome lead to inflammation and myeloid cell bias, revealing mechanisms involving aberrant cell death and ubiquitin pathway defects, and suggesting potential therapeutic targets.
- Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome Nature
- VEXAS syndrome research reveals overactive bone marrow stem cells may drive inflammation Medical Xpress
- hematopoietic stem and progenitor cells (IMAGE) EurekAlert!
- VEXAS Syndrome: Inflammation and Myeloid Bias Bioengineer.org
- Mutations in UBA1 Gene Linked to Myeloid Cell Bias and Inflammation in VEXAS Syndrome geneonline.com
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