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Inflammation

All articles tagged with #inflammation

Prednisone’s widespread use masks severe systemic risks
health14 days ago

Prednisone’s widespread use masks severe systemic risks

Prednisone, a top-40 U.S. prescription used by roughly 10 million people annually, offers rapid relief for inflammation but carries significant risks. While effective for short-term flare-ups of conditions like asthma or arthritis, its mechanism mimics cortisol, triggering metabolic, neurological, and cardiovascular changes. Experts warn that long-term use can lead to bone density loss, mood disorders, and adrenal crisis upon discontinuation. Medical guidelines increasingly favor steroid-sparing strategies, recommending brief, low-dose courses to mitigate these dangers.

via washingtonpost.com|
#corticosteroids#health#inflammation
Turmeric Unmasked: From Inflammation to Glow
wellness20 days ago

Turmeric Unmasked: From Inflammation to Glow

Turmeric contains curcumin, the compound behind its anti-inflammatory and antioxidant effects; while the whole spice provides modest curcumin, concentrated supplements offer higher doses with research strongest for inflammation and antioxidant protection and promising signals for digestion, brain and heart health, mood, and skin. For daily use, about 0.5–1 teaspoon of turmeric powder in foods is reasonable, while supplements range 500–2000 mg of curcumin per day—ideally after medical guidance. Boost absorption by pairing with black pepper and a fat source. Safety considerations include potential interactions with certain medications and conditions (gallbladder/kidney/liver issues); pregnant/breastfeeding individuals or those awaiting surgery should consult a clinician. Favor food-first intake and opt for third-party-tested supplements if used.

via vogue.com|
#curcumin#digestion#inflammation
Gum Health Linked to Higher Dementia Risk in 10-Year Japanese Study
health22 days ago

Gum Health Linked to Higher Dementia Risk in 10-Year Japanese Study

A decade-long study of about 1,400 adults in Japan found that worse gum health—more bleeding, receding gums, and larger gaps between teeth—was associated with a substantially higher risk of dementia over ten years (about 56% increase for all-cause dementia and 61% for Alzheimer's). While the study is observational and cannot prove causation, researchers note that periodontal inflammation and oral pathogens may influence brain health, and emphasize that dental care could potentially help reduce dementia risk. More diverse cohorts are needed to confirm the link.

via ScienceAlert|
#alzheimers-disease#dementia#gum-disease
Natural brake on inflammation found, hinting at safer anti-inflammatory drugs
science26 days ago

Natural brake on inflammation found, hinting at safer anti-inflammatory drugs

Researchers at UCL identified epoxy-oxylipins as natural brakes that help end inflammation. Inhibiting the enzyme soluble epoxide hydrolase (sEH) raises epoxy-oxylipin levels, speeding pain resolution and reducing intermediate monocytes—cells linked to chronic inflammation—through suppression of the p38 MAPK pathway. The study, conducted in humans using a safe drug approach, points to safer, immune-balancing therapies and potential trials for autoimmune and cardiovascular diseases.

via Science Daily|
#epoxy-oxylipins#inflammation#intermediate-monocytes
Could stomach bacterium H. pylori be linked to one-fifth of bowel cancers?
health27 days ago

Could stomach bacterium H. pylori be linked to one-fifth of bowel cancers?

A new meta-analysis pooling 43 studies (nearly 49 million people) suggests Helicobacter pylori infection could be linked with about 22% of bowel cancers worldwide, corresponding to a 1.6-fold higher risk for those infected, though it does not prove causation. When limited to more rigorous population-based and cohort studies, the estimated share drops to around 12%. Biological links are plausible via chronic stomach inflammation and shifts in the gut microbiome, but the exact chain to colorectal cancer remains unproven. Some observational studies hint that eradicating H. pylori might lower later risk after about ten years, but no randomized trials confirm this; established prevention remains screening and healthy lifestyle. Further research is needed to determine causality and whether testing or treatment would reduce colorectal cancer incidence.

via The Conversation|
#cancer-risk#colorectal-cancer#h-pylori
Aging on two fronts: a 117-year-old's body shows signs of aging and protection
health-and-medicine28 days ago

Aging on two fronts: a 117-year-old's body shows signs of aging and protection

Researchers analyzed Maria Branyas, 117, using multi-omics and found a paradox: signs of extreme aging (short telomeres, pro-inflammatory immune profile) coexisting with protective traits (neuro-/cardioprotection genes, very low inflammation, beneficial gut bacteria, and an epigenetic age younger than her chronological age). The study, on a person without major disease, offers a rare view of aging itself and suggests interventions could target the biology of aging rather than specific diseases.

via Science Daily|
#aging#epigenetics#health-and-medicine
Alcohol inflammation traps liver cells in a regeneration limbo, study finds
health1 month ago

Alcohol inflammation traps liver cells in a regeneration limbo, study finds

New research links alcohol-related liver disease to a failure of liver regeneration caused by inflammation-driven RNA mis-splicing and ESRP2 deficiency, trapping cells in a quasi-progenitor state; restoring ESRP2 levels or blocking inflammatory signals in lab tests improved splicing, suggesting diagnostic markers and potential therapies to help the liver recover.

via Science Daily|
#alcohol-related-liver-disease#esrp2#health
Shingrix May Help Heart Health, Study Suggests
health1 month ago

Shingrix May Help Heart Health, Study Suggests

An observational study of more than 70,000 adults 60+ found that those who received the Shingrix shingles vaccine had a lower risk of cardiovascular disease, heart failure, and stroke compared with those who got the older Zostavax vaccine, including about 9% longer cardiovascular disease-free time and 12% lower heart disease risk (and a 12% lower stroke risk in men). The study shows association, not causation, but researchers say preventing shingles may reduce vascular inflammation and immune activation; the vaccine’s AS01 adjuvant could play a role. Experts stress continuing established heart-healthy practices and note only about 42% of eligible adults are vaccinated, with access and cost issues influencing uptake.

via Prevention|
#cardiovascular-disease#health#inflammation
Calorie restriction may slow aging by taming immune protein C3
science1 month ago

Calorie restriction may slow aging by taming immune protein C3

In the NIH CALERIE trial, adults cutting calories by about 11–14% for two years showed a drop in the immune protein C3 in plasma. The study traced C3 back to age-related white adipose tissue, produced mainly by age-associated macrophages, and found that lowering C3 might reduce chronic inflammation linked to aging. In mice, pharmacologically inhibiting C3 decreased age-related inflammation, suggesting that the benefits of calorie restriction could be mimicked without weight loss. Researchers are now evaluating FDA-approved C3 inhibitors as a potential way to extend healthy lifespan while preserving immune function.

via ScienceDaily|
#adipose-tissue#aging#c3-complement
Sentivera inks up-to-$1.5B deal for inflammatory drug with Haisco
business1 month ago

Sentivera inks up-to-$1.5B deal for inflammatory drug with Haisco

Sentivera, formed by Arch Venture Partners and Population Health Partners after Metsera’s stealth exit, licensed an inflammatory-disease drug candidate to Haisco Pharmaceutical for up to about $1.5 billion, with $40 million cash upfront and stock valued at roughly $36 million for a 17.5% stake; Haisco retains Greater China rights, while Sentivera is positioned to advance the asset globally as a small-molecule therapy targeting Type 2 inflammatory diseases such as asthma and eczema.

via Fierce Biotech|
#biotech#business#inflammation
health1 month ago

Omega-3 and Low-Dose Aspirin Match Antibiotics for Severe Gum Disease

A 1-year, multicenter trial with 109 patients having advanced periodontitis found that adding omega-3 and low-dose aspirin to standard subgingival therapy produced outcomes nearly identical to those achieved with a standard antibiotic regimen. The benefits persisted six months after stopping treatment, suggesting a lasting modulation of the inflammatory response. While promising as an antibiotic-sparing option for select patients, researchers caution that more evidence is needed before replacing antibiotics in routine dental care.

via SciTechDaily|
#antibiotics#aspirin#health