Testosterone Therapy Linked to Acute Psychosis in Man With Klinefelter Syndrome

A case report describes a 45-year-old man who developed severe psychosis—hallucinations and hearing voices from his body—after a year of injectable testosterone for infertility and osteoporosis. He was later diagnosed with Klinefelter syndrome (XXY). Stopping testosterone and treating with antipsychotics led to recovery, and a cautious reintroduction at a lower dose with close monitoring did not prompt a relapse. The authors emphasize that this is a single case and does not prove causation, but hormone fluctuations may trigger psychiatric crises in vulnerable individuals, underscoring the need for psychiatric screening during hormone therapies.