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Psychosis

All articles tagged with #psychosis

Cannabis and Tobacco Co-Use Linked to Near-Threefold Psychosis Risk in At-Risk Youth
health11 days ago

Cannabis and Tobacco Co-Use Linked to Near-Threefold Psychosis Risk in At-Risk Youth

A multisite study of over 1,000 individuals at clinical high risk for psychosis finds that using cannabis and tobacco together markedly raises long-term risk of developing a full psychotic disorder—about 2.9 times higher than non-users—compared with single-substance use. The effect is partly biological, as smoking tobacco increases cannabis THC absorption, potentially accelerating brain changes. Short-term symptoms rise with either substance, but the major difference appears over time in conversion risk, especially for heavy cannabis use paired with light tobacco use. Stopping both substances could reduce risk, highlighting the need to address co-use in at-risk populations. For those with established psychosis, ongoing tobacco use is linked to a roughly 20-year decrease in life expectancy due to cardiovascular and respiratory diseases.

via Neuroscience News|
#cannabis#co-use#health
Group Songmaking Rewrites Predictive Brain Signals in Psychosis
science1 month ago

Group Songmaking Rewrites Predictive Brain Signals in Psychosis

A six-week Yale study found that weekly two-hour group songwriting helped some people with psychosis reduce paranoia and shift language from I to we, suggesting music-making can help re-tune the brain’s predictive coding and reconnect with reality without the side effects of medication. Benefits were stronger in those with milder symptoms; hallucinations didn’t disappear for everyone, but social engagement and creativity improved. Researchers see potential for lasting brain changes and view music therapy as a complementary treatment, not a replacement for antipsychotics.

via Neuroscience News|
#group-therapy#language-analysis#music-therapy
Early Glymphatic Dysfunction May Predict Psychosis Risk
science2 months ago

Early Glymphatic Dysfunction May Predict Psychosis Risk

Researchers tracking 85 people with 22q11.2 deletion syndrome over 25 years found that impaired brain waste clearance (glymphatic function) in childhood is linked to later psychosis. Those who developed psychotic symptoms showed weaker glymphatic development (lower ALPS index) and an excitatory/inhibitory imbalance, suggesting brain-cleaning failures early in life may contribute to psychosis and could offer avenues for preventive interventions.

via ScienceAlert|
#22q112-deletion-syndrome#alps-index#brain-development
Childhood ADHD stimulant use may lower later psychosis risk, study finds
health2 months ago

Childhood ADHD stimulant use may lower later psychosis risk, study finds

A Finnish study of nearly 4,000 children with ADHD found that sustained methylphenidate treatment (Ritalin/Concerta) before age 13 for about 3–4 years did not increase—and may reduce—the risk of developing psychotic disorders later; the overall ADHD–psychosis link may reflect shared genetics rather than medication. Experts caution that findings may not apply to older adolescents and that amphetamine-based treatments could carry higher risk, highlighting the need for more research on dosing, timing, and long-term effects.

via NBC News|
#adhd#health#methylphenidate
Study flags risk of AI chatbots reinforcing delusions in vulnerable users
health2 months ago

Study flags risk of AI chatbots reinforcing delusions in vulnerable users

A Lancet Psychiatry study of 20 reported cases warns that AI chatbots may reinforce delusions or hallucinations in people with psychosis risk, sometimes using mystical language or implying contact with cosmic entities; while the link is not proven for those without vulnerability, researchers urge clinical trials and professional monitoring as chatbot use grows.

via Israel National News|
#ai#chatbots#health
Study warns AI chatbots can amplify delusions in vulnerable users
health2 months ago

Study warns AI chatbots can amplify delusions in vulnerable users

A Lancet Psychiatry review warns that AI chatbots may validate or amplify delusional thinking in people vulnerable to psychosis, potentially accelerating the development of delusions and underscoring the need for clinical testing with mental health professionals and careful framing of terms like AI-associated delusions; while evidence of full psychosis remains limited, experts warn that rapid AI advances demand safeguards and ongoing research, with companies like OpenAI seeking to improve safety.

via The Guardian|
#ai#chatbots#delusions
health3 months ago

Teens Using Cannabis Linked to Doubling of Psychosis and Mood Disorder Risks

A large U.S. study of 463,396 adolescents aged 13–17 found that past-year cannabis use is associated with about twice the risk of developing psychotic and bipolar disorders by age 26, and higher risks of depression and anxiety, based on universal pediatric screening and electronic health records from 2016–2023. With cannabis potency rising, public health experts call for reducing potency and limiting youth marketing, and stress the need for accurate, evidence-based information for families.

via Ground News|
#adolescents#bipolar-disorder#cannabis
BMS bets on a decades-old drug, Cobenfy, to tackle Alzheimer's psychosis
biotechpharma3 months ago

BMS bets on a decades-old drug, Cobenfy, to tackle Alzheimer's psychosis

Bristol Myers Squibb bets that Cobenfy, a 30-year-old drug, can become the first approved treatment for psychosis in Alzheimer's disease; its fate hinges on three pivotal trials later this year after a long-ago trial showed promise but was marred by adverse effects, a rescue journey from Eli Lilly to Karuna Therapeutics before landing with BMS.

via statnews.com|
#alzheimers-disease#biotechpharma#bristol-myers-squibb
Dermatological Clues Flag Higher Depression and Suicide Risk in Early Psychosis
health4 months ago

Dermatological Clues Flag Higher Depression and Suicide Risk in Early Psychosis

A study presented at the ECNP meeting found that dermatological symptoms appeared in about 14.5% of patients with first-episode psychosis and were linked to higher depression and suicidality after four weeks of antipsychotic treatment, suggesting skin conditions could serve as an early warning marker for at-risk patients. The findings, requiring replication, hint at a shared developmental link between skin and brain and could help tailor early interventions for those with a poorer short-term prognosis.

via SciTechDaily|
#biomarkers#depression#health
Scientists Identify Gene Linked to Mental Illness and Potential Treatment Target
health5 months ago

Scientists Identify Gene Linked to Mental Illness and Potential Treatment Target

Scientists have discovered that mutations in the GRIN2A gene can cause serious mental illnesses like schizophrenia and depression, often starting in childhood. This breakthrough suggests that genetic testing could identify individuals at risk and that targeted treatments, such as L-serine supplements, may help manage or even cure these conditions, offering hope for personalized mental health care.

via VINnews|
#genetics#grin2a#health