Tag

Psychosis

All articles tagged with #psychosis

health1 month ago

Xenon Halts Depression Trials Over Psychosis Reports, Files Epilepsy NDA

Xenon Pharmaceuticals has voluntarily paused enrollment in its phase 3 depression trials for azetukalner after observing adverse events, including psychosis, in a small number of patients. The company continues treating existing participants but plans to adjust dosing to improve tolerability. Despite the setback, Xenon filed for FDA approval for the drug in focal seizures, citing robust safety data from epilepsy studies. Analysts view the pause as temporary and unrelated to a broader class safety issue, though the stock dropped 26% on the news.

via Fierce Biotech|

#azetukalner #clinical-trials #fda

celebrity-news1 month ago•15 min saved

Kelley Wolf apologizes to Scott Wolf after revealing psychosis diagnosis

Kelley Wolf publicly apologized to her estranged husband, Scott Wolf, and their three children after revealing a diagnosis of drug-induced mania with psychosis. The former couple, who separated in 2025, have since improved their relationship, with Scott supporting her public disclosure.

via Page Six|

#celebrity-news #divorce #kelley-wolf

health2 months ago•5 min saved

New Meta-Analysis Links Cannabis Use to Earlier Psychosis Onset, Especially in Adults Over 30

A large-scale meta-analysis published in Biological Psychiatry reveals that cannabis use is associated with an earlier onset of psychosis, with the gap widening significantly for older adults. While previous research focused on adolescent brain vulnerability, this study finds that the risk is most pronounced for those in their 30s and older, suggesting a cumulative effect of long-term use.

via The Independent|

#cannabis #health #mental-health

health2 months ago•25 min saved

Testosterone Injections Triggered Psychosis in Man with Undiagnosed Klinefelter Syndrome

A 45-year-old man developed acute psychosis, including auditory hallucinations, after one year of injectable testosterone therapy for osteoporosis and low testosterone. The case report, published in The Primary Care Companion for CNS Disorders, links the reaction to his undiagnosed Klinefelter syndrome. Symptoms resolved after stopping the hormone and starting antipsychotics, with a cautious reintroduction of lower-dose therapy later.

via PsyPost|

#case-report #health #hormone-replacement

health2 months ago•168 min saved

Salt swap gone wrong: AI dietary guidance linked to bromide poisoning and psychosis

A 60-year-old Seattle man seeking a healthier alternative to table salt asked ChatGPT for guidance and ended up consuming bromide salts, developing paranoia and hallucinations. His labs initially suggested high chloride, but further testing revealed bromide poisoning (bromism) causing the symptoms. He was hospitalized for three weeks, treated with electrolyte management and risperidone, and gradually recovered. The case highlights the dangers of relying on AI for medical advice and suggests clinicians consider bromism in unexplained psychiatric symptoms when patients report AI-influenced dietary changes.

via Live Science|

#bromide-poisoning #chatgpt #electrolyte-imbalance

crime2 months ago•4 min saved

Ex-husband recalls blood everywhere as MA mother faces murder trial

Patrick Clancy testified about the day he returned home to a quiet house, found Lindsay Clancy injured after she jumped from a second-floor window, and discovered his three children in the basement with exercise bands around their necks. Prosecutors say she strangled them; the defense argues she was suffering from psychosis. The Massachusetts trial is expected to last weeks, and if convicted Clancy faces life in prison without parole.

via BBC|

#crime #lindsay-clancy #murder-trial

technology3 months ago•16 min saved

ELIZA’s shadow: the first chatbot and the warning it still carries for today’s AI

Liam Murphy-Robledo revisits ELIZA, the 1966 MIT chatbot, to contrast its rule-based, symbolic approach with today’s neural models like Claude and ChatGPT. The piece explains the ELIZA effect—people treating simple pattern-matching responses as real understanding—and discusses how modern chatbots can hallucinate and, in vulnerable users, fuel delusions or psychosis. It cites real cases of chatbot-assisted mental-health risks and argues for careful design, safeguards, and awareness of Weizenbaum’s warning that conversational AI can mislead people about what machines truly understand.

via The Independent|

#chatbots #chatgpt #claude

health5 months ago•7 min saved

Cannabis and Tobacco Co-Use Linked to Near-Threefold Psychosis Risk in At-Risk Youth

A multisite study of over 1,000 individuals at clinical high risk for psychosis finds that using cannabis and tobacco together markedly raises long-term risk of developing a full psychotic disorder—about 2.9 times higher than non-users—compared with single-substance use. The effect is partly biological, as smoking tobacco increases cannabis THC absorption, potentially accelerating brain changes. Short-term symptoms rise with either substance, but the major difference appears over time in conversion risk, especially for heavy cannabis use paired with light tobacco use. Stopping both substances could reduce risk, highlighting the need to address co-use in at-risk populations. For those with established psychosis, ongoing tobacco use is linked to a roughly 20-year decrease in life expectancy due to cardiovascular and respiratory diseases.

via Neuroscience News|

#cannabis #co-use #health

health5 months ago•4 min saved

Cannabis and tobacco co-use linked to higher psychosis risk in at-risk individuals

In people at clinical high risk for psychosis, co-use of cannabis and tobacco over a two-year period nearly triples the risk of developing a psychotic disorder, signaling a potential synergistic effect and underscoring the need for replication and to test whether cessation reduces risk.

via Vanderbilt Health News|

#cannabis #co-use #health

science6 months ago•8 min saved

Group Songmaking Rewrites Predictive Brain Signals in Psychosis

A six-week Yale study found that weekly two-hour group songwriting helped some people with psychosis reduce paranoia and shift language from I to we, suggesting music-making can help re-tune the brain’s predictive coding and reconnect with reality without the side effects of medication. Benefits were stronger in those with milder symptoms; hallucinations didn’t disappear for everyone, but social engagement and creativity improved. Researchers see potential for lasting brain changes and view music therapy as a complementary treatment, not a replacement for antipsychotics.

via Neuroscience News|

#group-therapy #language-analysis #music-therapy

science6 months ago•5 min saved

Early Glymphatic Dysfunction May Predict Psychosis Risk

Researchers tracking 85 people with 22q11.2 deletion syndrome over 25 years found that impaired brain waste clearance (glymphatic function) in childhood is linked to later psychosis. Those who developed psychotic symptoms showed weaker glymphatic development (lower ALPS index) and an excitatory/inhibitory imbalance, suggesting brain-cleaning failures early in life may contribute to psychosis and could offer avenues for preventive interventions.

via ScienceAlert|

#22q112-deletion-syndrome #alps-index #brain-development

health6 months ago•5 min saved

Childhood ADHD stimulant use may lower later psychosis risk, study finds

A Finnish study of nearly 4,000 children with ADHD found that sustained methylphenidate treatment (Ritalin/Concerta) before age 13 for about 3–4 years did not increase—and may reduce—the risk of developing psychotic disorders later; the overall ADHD–psychosis link may reflect shared genetics rather than medication. Experts caution that findings may not apply to older adolescents and that amphetamine-based treatments could carry higher risk, highlighting the need for more research on dosing, timing, and long-term effects.

via NBC News|

#adhd #health #methylphenidate

health7 months ago•1 min saved

Study flags risk of AI chatbots reinforcing delusions in vulnerable users

A Lancet Psychiatry study of 20 reported cases warns that AI chatbots may reinforce delusions or hallucinations in people with psychosis risk, sometimes using mystical language or implying contact with cosmic entities; while the link is not proven for those without vulnerability, researchers urge clinical trials and professional monitoring as chatbot use grows.

via Israel National News|

#ai #chatbots #health

health7 months ago•4 min saved

Study warns AI chatbots can amplify delusions in vulnerable users

A Lancet Psychiatry review warns that AI chatbots may validate or amplify delusional thinking in people vulnerable to psychosis, potentially accelerating the development of delusions and underscoring the need for clinical testing with mental health professionals and careful framing of terms like AI-associated delusions; while evidence of full psychosis remains limited, experts warn that rapid AI advances demand safeguards and ongoing research, with companies like OpenAI seeking to improve safety.

via The Guardian|

#ai #chatbots #delusions

entertainment7 months ago•1 min saved

The Pitt Maps the Subtle Onset of Psychosis on TV

The HBO Max drama The Pitt follows a law student who spirals into psychosis, highlighting how early, subtle signs emerge over months and how his family's response and the show's portrayal contribute to broader conversations about mental health.

via The New York Times|

#entertainment #hbo-max #mental-health