Deep Brain Stimulation Alleviates Alzheimer's Symptoms.

Deep brain stimulation of newborn hippocampal neurons restored both cognitive and non-cognitive function in mouse models of Alzheimer’s disease. The neurons were modified by deep brain stimulation of the suprammamillary nucleus (SuM), which is located in the hypothalamus. Behavioral improvement in Alzheimer’s mice were seen only when these improved new neurons were activated by chemogenetics. The results suggested that multi-level enhancement of new neurons—enhancement in number, properties, and activity—is required for behavioral restoration in Alzheimer’s brains.